Zinc is both an intracellular and extracellular regulator of KATP channel function.
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Zinc as Allosteric Ion Channel Modulator: Ionotropic Receptors as MetalloproteinsThe Critical Roles of Zinc: Beyond Impact on Myocardial SignalingThe diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearanceInsulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels.ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation.Impact of disease-causing SUR1 mutations on the KATP channel subunit interface probed with a rhodamine protection assay.Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain.Human K(ATP) channelopathies: diseases of metabolic homeostasis.Zn(2+) induces hyperpolarization by activation of a K(+) channel and increases intracellular Ca(2+) and pH in sea urchin spermatozoaBiphasic modulation of ryanodine receptors by sulfhydryl oxidation in rat ventricular myocytesEffects of zinc supplementation and zinc chelation on in vitro β-cell function in INS-1E cells.The physiological role of drug transporters.EphA4 Receptor Forward Signaling Inhibits Glucagon Secretion From α-Cells.Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3beta.Snapshot Hyperspectral Light-Sheet Imaging of Signal Transduction in Live Pancreatic Islets.Insulin as a physiological modulator of glucagon secretion.Zinc homeostasis and signaling in health and diseases: Zinc signaling.A role for zinc in pancreatic islet β-cell cross-talk with the α-cell during hypoglycaemia.Zinc and insulin in pancreatic beta-cells.K(ATP) channels and islet hormone secretion: new insights and controversies.Divalent cations modulate TMEM16A calcium-activated chloride channels by a common mechanism.Inhibitory effect of zinc on glucose-stimulated zinc/insulin secretion in an insulin-secreting β-cell line.Genetic alteration of the metal/redox modulation of Cav3.2 T-type calcium channel reveals its role in neuronal excitability.Subunit-specific modulation of T-type calcium channels by zinc.Autocrine effect of Zn²⁺ on the glucose-stimulated insulin secretion.Zinc inactivates melastatin transient receptor potential 2 channels via the outer pore.Kv3 channel assembly, trafficking and activity are regulated by zinc through different binding sites.Increased free Zn2+ correlates induction of sarco(endo)plasmic reticulum stress via altered expression levels of Zn2+ -transporters in heart failure.The direct modulatory activity of zinc toward ion channels.Beneficial effect of zinc chloride and zinc ionophore pyrithione on attenuated cardioprotective potential of preconditioning phenomenon in STZ-induced diabetic rat heart.
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P2860
Zinc is both an intracellular and extracellular regulator of KATP channel function.
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2004 nî lūn-bûn
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Zinc is both an intracellular and extracellular regulator of KATP channel function.
@en
Zinc is both an intracellular and extracellular regulator of KATP channel function.
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label
Zinc is both an intracellular and extracellular regulator of KATP channel function.
@en
Zinc is both an intracellular and extracellular regulator of KATP channel function.
@nl
prefLabel
Zinc is both an intracellular and extracellular regulator of KATP channel function.
@en
Zinc is both an intracellular and extracellular regulator of KATP channel function.
@nl
P2093
P2860
P1476
Zinc is both an intracellular and extracellular regulator of KATP channel function.
@en
P2093
Alain Bloc
Anne-Lise Prost
Michel Vivaudou
Nicolas Hussy
Renaud Derand
P2860
P304
P356
10.1113/JPHYSIOL.2004.065094
P407
P577
2004-06-24T00:00:00Z