Zinc as a paracrine effector in pancreatic islet cell death.
about
SLC transporters as therapeutic targets: emerging opportunitiesA Possible Role for Metallic Ions in the Carbohydrate Cluster Recognition Displayed by a Lewis Y Specific AntibodyZinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function.The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearanceStructural optimization of Zn(II)-activated magnetic resonance imaging probes.Amplifying the sensitivity of zinc(II) responsive MRI contrast agents by altering water exchange rates.SLC30A3 responds to glucose- and zinc variations in beta-cells and is critical for insulin production and in vivo glucose-metabolism during beta-cell stress.A new gadolinium-based MRI zinc sensorZinc transporters and their role in the pancreatic β-cell.Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cellsMaternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition.Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland.Effects of zinc supplementation and zinc chelation on in vitro β-cell function in INS-1E cells.Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cellsZip4 mediated zinc influx stimulates insulin secretion in pancreatic beta cells.Noninvasive MRI of β-cell function using a Zn2+-responsive contrast agent.Methods of human islet culture for transplantation.Zinc-specific autometallographic in vivo selenium methods: tracing of zinc-enriched (ZEN) terminals, ZEN pathways, and pools of zinc ions in a multitude of other ZEN cells.Dietary zinc reduction, pyruvate supplementation, or zinc transporter 5 knockout attenuates β-cell death in nonobese diabetic mice, islets, and insulinoma cells.Imaging free zinc levels in vivo - what can be learned?Imaging trace element distributions in single organelles and subcellular featuresInvolvement of SIRT1 in Zn(2+), Streptozotocin, Non-Obese Diabetic, and Cytokine-Mediated Toxicities of β-cells.Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporterMechanism and regulation of cellular zinc transport.The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: therapeutic effects by chelators.Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.SLC30A8 mutations in type 2 diabetes.TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death.The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice.Exogenous metallothionein potentiates the insulin response at normal glucose concentrations in INS-1E beta-cells without disturbing intracellular ZnT8 expression.hZnT8 (Slc30a8) Transgenic Mice That Overexpress the R325W Polymorph Have Reduced Islet Zn2+ and Proinsulin Levels, Increased Glucose Tolerance After a High-Fat Diet, and Altered Levels of Pancreatic Zinc Binding Proteins.Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin.A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells.Expression of the ZIP/SLC39A transporters in β-cells: a systematic review and integration of multiple datasets.A two-site mechanism for the inhibition of IAPP amyloidogenesis by zinc.Metallothionein as an adaptive protein prevents diabetes and its toxicity.The Zn2+-transporting pathways in pancreatic beta-cells: a role for the L-type voltage-gated Ca2+ channel.Zinc is both an intracellular and extracellular regulator of KATP channel function.
P2860
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P2860
Zinc as a paracrine effector in pancreatic islet cell death.
description
2000 nî lūn-bûn
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2000 թուականի Մարտին հրատարակուած գիտական յօդուած
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
@zh-hk
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name
Zinc as a paracrine effector in pancreatic islet cell death.
@ast
Zinc as a paracrine effector in pancreatic islet cell death.
@en
type
label
Zinc as a paracrine effector in pancreatic islet cell death.
@ast
Zinc as a paracrine effector in pancreatic islet cell death.
@en
prefLabel
Zinc as a paracrine effector in pancreatic islet cell death.
@ast
Zinc as a paracrine effector in pancreatic islet cell death.
@en
P2093
P1433
P1476
Zinc as a paracrine effector in pancreatic islet cell death.
@en
P2093
P304
P356
10.2337/DIABETES.49.3.367
P407
P577
2000-03-01T00:00:00Z