Expression of the AID protein in normal and neoplastic B cells.
about
Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationHoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutationCoordinated expression of microRNA-155 and predicted target genes in diffuse large B-cell lymphomaRegulation of Aicda expression and AID activityImpact of linker strain and flexibility in the design of a fragment-based inhibitorIsotype-switched follicular lymphoma displays dissociation between activation-induced cytidine deaminase expression and somatic hypermutationEpstein-Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity.Immune Activation: Contribution to AIDS-Associated Non-Hodgkin LymphomaA target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expressionGANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response.PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cellsRegulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphomaLINE-1 retroelements complexed and inhibited by activation induced cytidine deaminase.B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.Absence of immunoglobulin class switch in primary lymphomas of the central nervous system.HCV infection and B-cell lymphomagenesisGenomic uracil homeostasis during normal B cell maturation and loss of this balance during B cell cancer development.Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm.Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genesDysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation.Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma.HSP90 inhibitors decrease AID levels and activity in mice and in human cells.AID to overcome the limitations of genomic information.Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma.IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functionsMolecular pathways in follicular lymphoma.GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.Alternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cells.Estrogen directly activates AID transcription and functionEpigenetics of the antibody responseAID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.DNA deaminases: AIDing hormones in immunity and cancer.UNG protects B cells from AID-induced telomere loss.Oncogenic mechanisms in Burkitt lymphomaHeterogeneity of genomic evolution and mutational profiles in multiple myeloma.
P2860
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P2860
Expression of the AID protein in normal and neoplastic B cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Expression of the AID protein in normal and neoplastic B cells.
@en
Expression of the AID protein in normal and neoplastic B cells.
@nl
type
label
Expression of the AID protein in normal and neoplastic B cells.
@en
Expression of the AID protein in normal and neoplastic B cells.
@nl
prefLabel
Expression of the AID protein in normal and neoplastic B cells.
@en
Expression of the AID protein in normal and neoplastic B cells.
@nl
P2093
P1433
P1476
Expression of the AID protein in normal and neoplastic B cells.
@en
P2093
Jane Houldsworth
Jessica Mohr
R S K Chaganti
Riccardo Dalla-Favera
Roberta Guglielmino
Roberto Polakiewicz
Said Aoufouchi
P304
P356
10.1182/BLOOD-2004-04-1558
P407
P577
2004-08-10T00:00:00Z