Impact of linker strain and flexibility in the design of a fragment-based inhibitor
about
Structure of uracil-DNA glycosylase fromMycobacterium tuberculosis: insights into interactions with ligandsUtilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of the Yersinia pestis Outer Protein H (YopH) Phosphatase ‡Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implicationsFragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial ChemistryUracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognitionFragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium.Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activitiesA rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH.Irreversible inhibition of DNA polymerase β by small-molecule mimics of a DNA lesionThe benefits of constructing leads from fragment hits.Fragment-based drug discovery using NMR spectroscopyEnhanced interrogation: emerging strategies for cell signaling inhibitionLigand deconstruction: Why some fragment binding positions are conserved and others are notAutomated library synthesis of cyclopropyl boronic esters employing diazomethane in a tube-in-tube flow reactor.Exquisitely specific bisubstrate inhibitors of c-Src kinase.Stereodivergent synthesis of right- and left-handed iminoxylitol heterodimers and monomers. Study of their impact on β-glucocerebrosidase activity.Fragment informatics and computational fragment-based drug design: an overview and update.Probing secondary interactions in biomolecular recognition by dynamic combinatorial chemistry.Compound Design by Fragment-Linking.Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.The good, the bad and the twisted: a survey of ligand geometry in protein crystal structures.Probing the reaction coordinate of the p300/CBP histone acetyltransferase with bisubstrate analogs.The TEAD4-YAP/TAZ protein-protein interaction: expected similarities and unexpected differences.Understanding the role of domain-domain linkers in the spatial orientation of domains in multi-domain proteins.The price of flexibility - a case study on septanoses as pyranose mimetics.A fragment-based approach to the SAMPL3 Challenge
P2860
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P2860
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
@ast
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
@en
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
@nl
type
label
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
@ast
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
@en
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
@nl
prefLabel
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
@ast
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
@en
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
@nl
P2093
P2860
P3181
P356
P1476
Impact of linker strain and flexibility in the design of a fragment-based inhibitor
@en
P2093
James T Stivers
Jared B Parker
Suhman Chung
P2860
P2888
P304
P3181
P356
10.1038/NCHEMBIO.163
P577
2009-06-01T00:00:00Z
P5875
P6179
1049081708