The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism.
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Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting stepsIdentification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arraysUBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnoverThe UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradationDetailed structural insights into the p97-Npl4-Ufd1 interfaceThe Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM): MUTUALLY EXCLUSIVE BINDING OF COFACTORS TO THE N-TERMINAL DOMAIN OF p97Structural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP)The budding yeast Cdc48(Shp1) complex promotes cell cycle progression by positive regulation of protein phosphatase 1 (Glc7).The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48pSel1p/Ubx2p participates in a distinct Cdc48p-dependent endoplasmic reticulum-associated degradation pathway.Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulumA conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathwayThe p97 ATPase associates with EEA1 to regulate the size of early endosomesThe general definition of the p97/valosin-containing protein (VCP)-interacting motif (VIM) delineates a new family of p97 cofactorsHereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformationControl of p97 function by cofactor bindingConformational changes in the AAA ATPase p97-p47 adaptor complexProtection of armadillo/β-Catenin by armless, a novel positive regulator of wingless signalingStructural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated DegradationWss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugatesInvolvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptorsSmall but versatile: the extraordinary functional and structural diversity of the beta-grasp foldA Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Regulation of mitochondrial genome inheritance by autophagy and ubiquitin-proteasome system: implications for health, fitness, and fertilityDelivery of ubiquitinated substrates to protein-unfolding machines.The p97 ATPase dislocates MHC class I heavy chain in US2-expressing cells via a Ufd1-Npl4-independent mechanism.Derlin-1 regulates mutant VCP-linked pathogenesis and endoplasmic reticulum stress-induced apoptosis.Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action.p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association?ATP binding to p97/VCP D1 domain regulates selective recruitment of adaptors to its proximal N-domain.The complexities of p97 function in health and diseaseUbiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response.Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum.Structural insights into the p97-Ufd1-Npl4 complex.Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopyChromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD)Structural and functional deviations in disease-associated p97 mutants.VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
P2860
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P2860
The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
The AAA ATPase p97/VCP interac ...... n bipartite binding mechanism.
@en
The AAA ATPase p97/VCP interac ...... n bipartite binding mechanism.
@nl
type
label
The AAA ATPase p97/VCP interac ...... n bipartite binding mechanism.
@en
The AAA ATPase p97/VCP interac ...... n bipartite binding mechanism.
@nl
prefLabel
The AAA ATPase p97/VCP interac ...... n bipartite binding mechanism.
@en
The AAA ATPase p97/VCP interac ...... n bipartite binding mechanism.
@nl
P2093
P2860
P356
P1476
The AAA ATPase p97/VCP interac ...... n bipartite binding mechanism.
@en
P2093
Catherine Brasseur
Hemmo H Meyer
Roland M Bruderer
P2860
P304
49609-49616
P356
10.1074/JBC.M408695200
P407
P577
2004-09-15T00:00:00Z