Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.
about
Botanical dietary supplements gone badBalkan endemic nephropathy: an update on its aetiologyMechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approachesContributions of human enzymes in carcinogen metabolismGene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in ratsCytochrome P450 1A2 detoxicates aristolochic acid in the mouse.Contribution of biotransformation enzymes to the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions, difficult answersDetoxification of aristolochic acid I by O-demethylation: less nephrotoxicity and genotoxicity of aristolochic acid Ia in rodents.The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes.Genetic loci that affect aristolochic acid-induced nephrotoxicity in the mouseAristolochic acid causes albuminuria by promoting mitochondrial DNA damage and dysfunction in podocyte.Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.Aristolochic acid I metabolism in the isolated perfused rat kidney.Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor.Omeprazole Alleviates Aristolochia manshuriensis Kom-Induced Acute Nephrotoxicity.A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.Prediction and Characterisation of the System Effects of Aristolochic Acid: A Novel Joint Network Analysis towards Therapeutic and Toxicological Mechanisms.Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivoBiological reactive intermediates (BRIs) formed from botanical dietary supplementsp53 mutations as fingerprints for aristolochic acid: an environmental carcinogen in endemic (Balkan) nephropathy.beta-Naphthoflavone protects mice from aristolochic acid-I-induced acute kidney injury in a CYP1A dependent mechanism.Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid.A retrospective review of patients with urothelial cancer in 3,370 recipients after renal transplantation: a single-center experience.Profiling of mRNA and long non-coding RNA of urothelial cancer in recipients after renal transplantation.Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats.Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity.Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches.DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer.Environmental toxin-induced acute kidney injury.Extrahepatic Drug-Metabolizing Enzymes and Their Significance
P2860
Q24647313-FA9310EE-9401-4FAB-A6EB-339566A6530AQ28079308-BDDC87DA-C4D9-4706-8226-792602F06926Q28390347-D356B4C8-9EC1-486F-BB35-5B3791659E40Q30520640-7D7B3999-9EE6-4EBF-A85E-C68721964589Q33264201-145DBD49-0562-4E22-8121-A99D8A3A21D0Q33861885-C6F94DE1-72F7-46F9-8D93-53707CE1DA2AQ34359592-AF4155EC-A317-4638-8ADE-7BEEB38062A0Q34481483-F238BE35-77C6-4B9C-8025-F2BBE0FE6C67Q35016427-30FC75B0-5D03-4F3C-9580-1C216943F593Q35057152-096B25C5-23C2-44A3-A4A6-0D9C8A8DCC56Q35070951-1582DD8E-F596-4658-9E95-E50CC08A1E4FQ35685368-CB5AFE79-94EB-4603-96EC-7CC2931E43BEQ35747023-B203A8A5-8C3D-48E5-B12F-1E564F3B2210Q35902655-312B84AA-DB07-4031-AF99-0545A3BC6A83Q36157755-4A7A128C-F616-4AF5-8F37-73D549A564A7Q36324758-94945E31-6A3C-4A21-86AA-250AB17E7C27Q36333565-B1186DB0-179E-484B-B902-0880520206FCQ36667086-B3BC81B0-2B05-4C6F-A4E2-489ADA15A759Q36721027-41F829D5-39A2-4BFD-AC14-E9A31BB2D100Q36996161-AAA5C980-2A4A-4B0B-B067-6B635EF9C806Q37311820-3B61104C-F106-4D8A-8656-848201412F81Q37729300-DC7038A0-29E3-4CA6-AD9A-43D9BAEA316FQ38154957-A9F4ABDE-8DF2-4A23-88AC-18A144BF4DBFQ38252737-68F229E2-D7C7-43A8-9E42-D6142E510E78Q38441306-C451499C-7706-4B67-9A42-A7E1357F2E2CQ42157886-3FE4F176-22A0-41FF-A0D6-58BB67E31E58Q42704240-DE195DD1-1851-4601-B38D-A126D389C499Q42733526-F77AF117-FA09-49DC-A349-8E92AB1C4576Q45018797-A68184EB-EA3E-4309-A9F2-7CB23425493CQ47096788-552EC5FB-94DE-4905-84A1-9DB0774EDEBCQ47099055-3C3ED384-79CE-4233-872F-AE11A0C42797Q57258718-527B240D-C39A-4E92-8EB5-5334C4303837
P2860
Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Human hepatic and renal micros ...... tients with urothelial cancer.
@en
Human hepatic and renal micros ...... tients with urothelial cancer.
@nl
type
label
Human hepatic and renal micros ...... tients with urothelial cancer.
@en
Human hepatic and renal micros ...... tients with urothelial cancer.
@nl
prefLabel
Human hepatic and renal micros ...... tients with urothelial cancer.
@en
Human hepatic and renal micros ...... tients with urothelial cancer.
@nl
P2093
P2860
P356
P1476
Human hepatic and renal micros ...... atients with urothelial cancer
@en
P2093
Heinz H Schmeiser
Manfred Wiessler
P2860
P304
P356
10.1002/IJC.20564
P577
2005-01-01T00:00:00Z