Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.
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Botanical dietary supplements gone badBalkan endemic nephropathy: an update on its aetiologyCytochrome P450 1A2 detoxicates aristolochic acid in the mouse.Contribution of biotransformation enzymes to the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions, difficult answersDetoxification of aristolochic acid I by O-demethylation: less nephrotoxicity and genotoxicity of aristolochic acid Ia in rodents.Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.Genetic loci that affect aristolochic acid-induced nephrotoxicity in the mouseDrug bioactivation, covalent binding to target proteins and toxicity relevance.A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivoInfluence of structural and functional modifications of selected genotoxic carcinogens on metabolism and mutagenicity - a review.Biological reactive intermediates (BRIs) formed from botanical dietary supplementsSulfotransferase-1A1-dependent bioactivation of aristolochic acid I and N-hydroxyaristolactam I in human cells.Bioactivation of herbal constituents: simple alerts in the complex system.Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid.Y27632 attenuates the aristolochic acid-promoted invasion and migration of human urothelial cancer TSGH cells in vitro and inhibits the growth of xenografts in vivo.Human sulphotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue.Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats.Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity.In silico toxicological screening of natural products.Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy.DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling.Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches.Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.Study on the nitric oxide generating effects from aristolochic acid in vitro.Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury.DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer.Cytotoxicity of phenanthrenes extracted from Aristolochia contorta in human proximal tubular epithelial cell line.Food chemistry and chemophobia
P2860
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P2860
Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Carcinogenic aristolochic acid ...... ith Chinese herbs nephropathy.
@ast
Carcinogenic aristolochic acid ...... ith Chinese herbs nephropathy.
@en
Carcinogenic aristolochic acid ...... ith Chinese herbs nephropathy.
@nl
type
label
Carcinogenic aristolochic acid ...... ith Chinese herbs nephropathy.
@ast
Carcinogenic aristolochic acid ...... ith Chinese herbs nephropathy.
@en
Carcinogenic aristolochic acid ...... ith Chinese herbs nephropathy.
@nl
prefLabel
Carcinogenic aristolochic acid ...... ith Chinese herbs nephropathy.
@ast
Carcinogenic aristolochic acid ...... ith Chinese herbs nephropathy.
@en
Carcinogenic aristolochic acid ...... ith Chinese herbs nephropathy.
@nl
P2093
P356
P1433
P1476
Carcinogenic aristolochic acid ...... with Chinese herbs nephropathy
@en
P2093
Heinz H Schmeiser
Manfred Wiessler
P304
P356
10.1093/CARCIN/23.4.617
P407
P577
2002-04-01T00:00:00Z