Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors.
about
Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner earRLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancerAkt1 in osteoblasts and osteoclasts controls bone remodeling.Validation of anti-aging drugs by treating age-related diseases.Selective signaling by Akt2 promotes bone morphogenetic protein 2-mediated osteoblast differentiation.Bone Size and Quality Regulation: Concerted Actions of mTOR in Mesenchymal Stromal Cells and OsteoclastsTGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathwaysAKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.Regulation of pancreatic duct cell differentiation by phosphatidylinositol-3 kinase.Src inhibitors in the treatment of metastatic bone disease: rationale and clinical dataHypoxia enhances the proliferative response of macrophages to CSF-1 and their pro-survival response to TNF.Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1.Unraveling the role of FoxOs in bone--insights from mouse models.Distinct actions of akt1 on skeletal architecture and functionTumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.Activity of everolimus (RAD001) in relapsed and/or refractory multiple myeloma: a phase I study.Pathway analysis of microRNA expression profile during murine osteoclastogenesisRole of extracellular matrix renal tubulo-interstitial nephritis antigen (TINag) in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B-serine/threonine kinase (AKT) signalGab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development.Erythropoietin mediated bone formation is regulated by mTOR signaling.Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development.Mutation in Osteoactivin Promotes Receptor Activator of NFκB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast FunctionRegulation of IKKε Expression by Akt2 Isoform.A short report: PAMM, a novel antioxidant protein, induced by oxidative stress.alphavbeta3 and macrophage colony-stimulating factor: partners in osteoclast biology.Molecular mechanism of the life and death of the osteoclast.Future anti-catabolic therapeutic targets in bone disease.Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in boneCross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis.Fyn promotes proliferation, differentiation, survival and function of osteoclast lineage cellsTargeted overexpression of BSP in osteoclasts promotes bone metastasis of breast cancer cellsTrolox prevents osteoclastogenesis by suppressing RANKL expression and signaling.Rheumatoid factor positivity is associated with increased joint destruction and upregulation of matrix metalloproteinase 9 and cathepsin k gene expression in the peripheral blood in rheumatoid arthritic patients treated with methotrexateDistinct actions of Akt1 and Akt2 in skeletal muscle differentiation.RelB-induced expression of Cot, an MAP3K family member, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα.Bim: guardian of tissue homeostasis and critical regulator of the immune system, tumorigenesis and bone biology.Heterogeneous drug target expression as possible basis for different clinical and radiological response to the treatment of primary and metastatic renal cell carcinoma: suggestions from bench to bedside.AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1The Effect of Everolimus in an In Vitro Model of Triple Negative Breast Cancer and Osteoclasts.
P2860
Q27341203-7B5A2A5F-3CEA-4AF1-B1CC-E514B6D3AF69Q28482104-D011D37A-45F5-410D-B8D3-DBB6DB625473Q33303666-3BB7D994-58C4-4D36-945E-43DBFDECC241Q33588700-5EB98311-9241-4889-A8BC-96E60A9D9982Q33627269-642CB0CC-30CE-4921-B0DB-A4BC76E7B6C0Q33794615-B9690F88-4E23-4DCF-A92D-C56F30F46064Q33851600-286063C2-2E0F-432A-9281-2D89D5CDC1DDQ33871498-30CE26D0-B28A-42E9-9867-33D0350EACD9Q34110611-D9A970F7-9F44-45F1-8843-C777EE038A4EQ34182834-31F9BC0E-5A20-492A-8105-4F95436CBA53Q34430216-3CB28360-0EFF-4340-9CDD-CE8839ECE219Q34510163-70ACA7EF-EF97-46C1-9B2F-13F9543DDC20Q34752434-A4975BC4-E073-4727-8776-D78F02B7D5D0Q35126991-3480FECC-759B-40F8-B02B-704BE80B2789Q35129460-D5DE16D7-927C-4E67-BFEE-F9BD3F19A541Q35149607-75BB9D05-FC38-4678-B84B-EB011EB1719BQ35236076-9EEE046F-23D3-4A0F-BB3D-EFC37026DBD0Q35252690-3AEA950E-DE56-451C-B78A-2660DB598066Q35310728-702AA52F-917A-45FD-B471-3D5F42AEF207Q35531128-AD9BCFC1-D918-4927-A81C-A1AA88704C74Q35613027-45597CC6-19ED-46D5-845B-4CA12C74304DQ35665655-47FBB78C-296B-411B-BC31-6BEDEBD5A8A4Q35953074-0F68841A-EFDB-4EC6-ACB3-CE4648664206Q36047103-CB56D8CD-5EE6-4D6C-B0E4-3AF2140C8D35Q36106338-8ADC6C1A-9156-42AD-A837-E0319E69EF75Q36324934-2252B9CF-8C30-4940-83E3-B038BBF86B16Q36532524-DF912AAB-E37D-47D7-979C-AC5384210BBBQ36532578-7F89BC5D-66D5-4D00-A033-DD94ED90005CQ36926972-8BD4565A-A5BB-4F7C-B47D-4EE74E0FA643Q36968719-E3F2CBD6-16D6-4059-8614-FB2943D9DF3AQ37035480-C8169101-2D22-453F-A168-CDFF8DCEF4A0Q37152195-41155F38-2BE2-46C9-9C0B-1B3375292EC5Q37185295-F5644EDD-1080-415E-BC9D-7F29C384AD3DQ37358983-7AD5B95E-1734-469F-8D2F-1D6F5D162676Q37361165-982315CE-368F-4CE1-8FFC-E23C3F517815Q37635761-49D220A7-1C18-4958-A0CD-1C7055F911CBQ37883974-B25F844D-404B-479E-9009-2C7CB137F0D0Q38171327-6240E05D-350D-4D33-8C68-BFF63901D7ABQ38348926-38502D13-DB39-4E8B-9E02-7D3EDBD58CF9Q38733725-FE40E20A-C283-48AB-9813-78417A2D0579
P2860
Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Akt1/Akt2 and mammalian target ...... solated osteoclast precursors.
@en
Akt1/Akt2 and mammalian target ...... solated osteoclast precursors.
@nl
type
label
Akt1/Akt2 and mammalian target ...... solated osteoclast precursors.
@en
Akt1/Akt2 and mammalian target ...... solated osteoclast precursors.
@nl
prefLabel
Akt1/Akt2 and mammalian target ...... solated osteoclast precursors.
@en
Akt1/Akt2 and mammalian target ...... solated osteoclast precursors.
@nl
P2860
P356
P1476
Akt1/Akt2 and mammalian target ...... solated osteoclast precursors.
@en
P2093
Keith A Hruska
Toshifumi Sugatani
P2860
P304
P356
10.1074/JBC.M410480200
P407
P577
2004-11-15T00:00:00Z