Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.
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α-RgIA, a Novel Conotoxin That Blocks the α9α10 nAChR: Structure and Identification of Key Receptor-Binding ResiduesCharacterization of a Novel α-Conotoxin TxID from Conus textile That Potently Blocks Rat α3β4 Nicotinic Acetylcholine ReceptorsResidues Responsible for the Selectivity of α-Conotoxins for Ac-AChBP or nAChRsStructures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformationsBlockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculationsStructural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.New tools for targeted disruption of cholinergic synaptic transmission in Drosophila melanogaster.Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.Use of venom peptides to probe ion channel structure and function.Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors.Chemical synthesis and characterization of two α4/7-conotoxinsInhibition of cholinergic pathways in Drosophila melanogaster by α-conotoxins.A novel 4/6-type alpha-conotoxin ViIA selectively inhibits nAchR α3β2 subtype.Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli.Muscle and neuronal nicotinic acetylcholine receptors. Structure, function and pathogenicity.Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads.Design of new α-conotoxins: from computer modeling to synthesis of potent cholinergic compounds.α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition.Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives.Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors.The three-dimensional structure of the analgesic alpha-conotoxin, RgIA.α-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to α7-nAChR overexpressed non-small cell lung cancer.Expression and functional properties of α7 acetylcholine nicotinic receptors are modified in the presence of other receptor subunits.Sympathetic α₃β₂-nAChRs mediate cerebral neurogenic nitrergic vasodilation in the swine.A potentially novel nicotinic receptor in Aplysia neuroendocrine cells.Epimerization-free access to C-terminal cysteine peptide acids, carboxamides, secondary amides, and esters via complimentary strategies.Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails.
P2860
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P2860
Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Alpha-conotoxins ImI and ImII ...... n nicotinic receptor subtypes.
@en
Alpha-conotoxins ImI and ImII ...... n nicotinic receptor subtypes.
@nl
type
label
Alpha-conotoxins ImI and ImII ...... n nicotinic receptor subtypes.
@en
Alpha-conotoxins ImI and ImII ...... n nicotinic receptor subtypes.
@nl
prefLabel
Alpha-conotoxins ImI and ImII ...... n nicotinic receptor subtypes.
@en
Alpha-conotoxins ImI and ImII ...... n nicotinic receptor subtypes.
@nl
P2093
P356
P1433
P1476
Alpha-conotoxins ImI and ImII ...... n nicotinic receptor subtypes.
@en
P2093
Baldomero M Olivera
Hai-Long Wang
J Michael McIntosh
Michael Ellison
Steven M Sine
P304
16019-16026
P356
10.1021/BI048918G
P407
P577
2004-12-01T00:00:00Z