The antimicrobial antiproteinase elafin binds to lipopolysaccharide and modulates macrophage responses.
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WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lungElafin is a biomarker of graft-versus-host disease of the skinSheep lung segmental delivery strategy demonstrates adenovirus priming of local lung responses to bacterial LPS and the role of elafin as a response modulatorStructural and antimicrobial properties of human pre-elafin/trappin-2 and derived peptides against Pseudomonas aeruginosa.Functional characterization of polymorphisms in the peptidase inhibitor 3 (elafin) gene and validation of their contribution to risk of acute respiratory distress syndrome.Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:CAnti-HIV-1 activity of elafin depends on its nuclear localization and altered innate immune activation in female genital epithelial cells.A functional variant of elafin with improved anti-inflammatory activity for pulmonary inflammation.Anti-HIV-1 activity of elafin is more potent than its precursor's, trappin-2, in genital epithelial cellsDecreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation.Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosisAntiviral activity of trappin-2 and elafin in vitro and in vivo against genital herpes.Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitmentIntracellular secretory leukoprotease inhibitor modulates inositol 1,4,5-triphosphate generation and exerts an anti-inflammatory effect on neutrophils of individuals with cystic fibrosis and chronic obstructive pulmonary disease.Secretory leukocyte protease inhibitor and elafin/trappin-2: versatile mucosal antimicrobials and regulators of immunity.WAP domain proteins as modulators of mucosal immunity.War and peace between WAP and HIV: role of SLPI, trappin-2, elafin and ps20 in susceptibility to HIV infection.SLPI and elafin: multifunctional antiproteases of the WFDC family.SLPI and trappin-2 as therapeutic agents to target airway serine proteases in inflammatory lung diseases: current and future directions.Therapeutic potential of human elafin.From bench to bedside: discovery of ovarian cancer biomarkers using high-throughput technologies in the past decade.A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung.Human pre-elafin inhibits a Pseudomonas aeruginosa-secreted peptidase and prevents its proliferation in complex media.Characterization of human pre-elafin mutants: full antipeptidase activity is essential to preserve lung tissue integrity in experimental emphysema.The antimicrobial/elastase inhibitor elafin regulates lung dendritic cells and adaptive immunity.The antibacterial and antifungal properties of trappin-2 (pre-elafin) do not depend on its protease inhibitory function.Airway Epithelium Dysfunction in Cystic Fibrosis and COPD.Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase.
P2860
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P2860
The antimicrobial antiproteinase elafin binds to lipopolysaccharide and modulates macrophage responses.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
@zh-hans
2005年学术文章
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2005年學術文章
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name
The antimicrobial antiproteina ...... odulates macrophage responses.
@en
The antimicrobial antiproteina ...... odulates macrophage responses.
@nl
type
label
The antimicrobial antiproteina ...... odulates macrophage responses.
@en
The antimicrobial antiproteina ...... odulates macrophage responses.
@nl
prefLabel
The antimicrobial antiproteina ...... odulates macrophage responses.
@en
The antimicrobial antiproteina ...... odulates macrophage responses.
@nl
P2093
P2860
P356
P1476
The antimicrobial antiproteina ...... odulates macrophage responses.
@en
P2093
Ali Roghanian
Jean-Michel Sallenave
Jonathan W McMichael
Robert Ramage
P2860
P304
P356
10.1165/RCMB.2004-0250OC
P577
2005-01-24T00:00:00Z