Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits.
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How structure shapes (dys)function: a perspective to understanding brain region-specific degeneration in prion diseaseOral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected miceEarly neurodegeneration progresses independently of microglial activation by heparan sulfate in the brain of mucopolysaccharidosis IIIB miceEarly behavioral changes and quantitative analysis of neuropathological features in murine prion disease: stereological analysis in the albino Swiss mice model.The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases.A Drosophila model of GSS syndrome suggests defects in active zones are responsible for pathogenesis of GSS syndrome.Morphological and functional abnormalities in mitochondria associated with synaptic degeneration in prion disease.At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response.Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures.Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease.Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease.Reduced expression of the presynaptic co-chaperone cysteine string protein alpha (CSPα) does not exacerbate experimentally-induced ME7 prion diseaseStriatal pathology underlies prion infection-mediated hyperactivity in mice.Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegenerationPrion Strain Differences in Accumulation of PrPSc on Neurons and Glia Are Associated with Similar Expression Profiles of Neuroinflammatory Genes: Comparison of Three Prion StrainsAssessing burrowing, nest construction, and hoarding in miceDNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative diseaseAt the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei.Differential molecular chaperone response associated with various mouse adapted scrapie strains.The prion strain phenomenon: molecular basis and unprecedented features.Acute kidney injury leads to inflammation and functional changes in the brain.Identification and removal of proteins that co-purify with infectious prion protein improves the analysis of its secondary structure.Therapy for prion diseases: Insights from the use of RNA interference.Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration.Prion neurodegeneration: starts and stops at the synapse.Rescuing neurons in prion disease.Cerebellar compartmentation of prion pathogenesis.The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity.Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies.Cytosolically expressed PrP GPI-signal peptide interacts with mitochondria.Transcriptional changes in the brains of cattle orally infected with the bovine spongiform encephalopathy agent precede detection of infectivity.Burrowing is a sensitive behavioural assay for monitoring general wellbeing during dextran sulfate sodium colitis in laboratory mice.The assessment of general well-being using spontaneous burrowing behaviour in a short-term model of chemotherapy-induced mucositis in the ratCSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Aβ42, t-tau and p-tau
P2860
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P2860
Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Neuropathologically distinct p ...... ofiles of behavioral deficits.
@en
Neuropathologically distinct p ...... ofiles of behavioral deficits.
@nl
type
label
Neuropathologically distinct p ...... ofiles of behavioral deficits.
@en
Neuropathologically distinct p ...... ofiles of behavioral deficits.
@nl
prefLabel
Neuropathologically distinct p ...... ofiles of behavioral deficits.
@en
Neuropathologically distinct p ...... ofiles of behavioral deficits.
@nl
P2093
P1476
Neuropathologically distinct p ...... ofiles of behavioral deficits.
@en
P2093
P304
P356
10.1016/J.NBD.2004.08.015
P577
2005-03-01T00:00:00Z