Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.
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The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptideNeurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratioPeptides that form β-sheets on hydrophobic surfaces accelerate surface-induced insulin amyloidal aggregationAmyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastinLipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in micePlasticity of Candida albicans BiofilmsTransient dynamics of Aβ contribute to toxicity in Alzheimer's diseaseOn the Environmental Factors Affecting the Structural and Cytotoxic Properties of IAPP PeptidesAbeta mediated diminution of MTT reduction--an artefact of single cell culture?Amyloid-β protofibrils: size, morphology and synaptotoxicity of an engineered mimicβ-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide ADisassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathwaysRole of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathwayHeterogeneity in primary structure, post-translational modifications, and germline gene usage of nine full-length amyloidogenic kappa1 immunoglobulin light chainsThermodynamic selection of steric zipper patterns in the amyloid cross-beta spineLow density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.Amyloid structure and assembly: insights from scanning transmission electron microscopy.Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicityCDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeletonAmyloid-β peptide structure in aqueous solution varies with fragment size.Cytotoxicity of superoxide dismutase 1 in cultured cells is linked to Zn2+ chelation.Role of TRPM2 in H(2)O(2)-induced cell apoptosis in endothelial cells.Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer diseaseMultivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicityAbeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species.The many faces of α-synuclein: from structure and toxicity to therapeutic target.Ashwagandha (Withania somnifera) reverses β-amyloid1-42 induced toxicity in human neuronal cells: implications in HIV-associated neurocognitive disorders (HAND).Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaquesNovel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease.Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calciumStructural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease.Discovery and Characterization of Nonpeptidyl Agonists of the Tissue-Protective Erythropoietin ReceptorEffects of peptides derived from terminal modifications of the aβ central hydrophobic core on aβ fibrillization.Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species.Monomeric Aβ(1-40) and Aβ(1-42) Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil.Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death.Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretinRecent insights in islet amyloid polypeptide-induced membrane disruption and its role in beta-cell death in type 2 diabetes mellitusPre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity.Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease.
P2860
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P2860
Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Nucleation-dependent polymeriz ...... -mediated neuronal cell death.
@en
Nucleation-dependent polymeriz ...... -mediated neuronal cell death.
@nl
type
label
Nucleation-dependent polymeriz ...... -mediated neuronal cell death.
@en
Nucleation-dependent polymeriz ...... -mediated neuronal cell death.
@nl
prefLabel
Nucleation-dependent polymeriz ...... -mediated neuronal cell death.
@en
Nucleation-dependent polymeriz ...... -mediated neuronal cell death.
@nl
P2093
P1476
Nucleation-dependent polymeriz ...... d-mediated neuronal cell death
@en
P2093
Damian Cunningham
Kyle Powell
Mark Wogulis
Russell E Rydel
Sarah Wright
Tamie Chilcote
P304
P356
10.1523/JNEUROSCI.2381-04.2005
P407
P577
2005-02-01T00:00:00Z