An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.
about
Understanding functional residues of the cannabinoid CB1.Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanismsChemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signallingMolecular dynamics simulations of rhodopsin point mutants at the cytoplasmic side of helices 3 and 6.Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkStructural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms.Thermostabilisation of an agonist-bound conformation of the human adenosine A(2A) receptor.The role of Cysteine 6.47 in class A GPCRsModulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism.Molecular Insights into the Transmembrane Domain of the Thyrotropin ReceptorDifferential determinants for coupling of distinct G proteins with the class B secretin receptor.Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptorsAn intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.Agonist binding, agonist affinity and agonist efficacy at G protein-coupled receptorsNovel insights on thyroid-stimulating hormone receptor signal transduction.The seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions.Dynamic conformational responses of a human cannabinoid receptor-1 helix domain to its membrane environment.The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression.Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain.Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation.Biased Gs versus Gq proteins and β-arrestin signaling in the NK1 receptor determined by interactions in the water hydrogen bond networkFrom molecular details of the interplay between transmembrane helices of the thyrotropin receptor to general aspects of signal transduction in family a G-protein-coupled receptors (GPCRs).Structure and activation of the TSH receptor transmembrane domain.A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors.PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation.Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor.Dissecting the conserved NPxxY motif of the M3 muscarinic acetylcholine receptor: critical role of Asp-7.49 for receptor signaling and multiprotein complex formation.Linking agonist binding to histamine H1 receptor activation.Accelerated molecular dynamics simulations of the octopamine receptor using GPUs: discovery of an alternate agonist-binding position.Mapping histamine H4receptor–ligand binding modesStructure-based virtual screening for fragment-like ligands of the G protein-coupled histamine H4 receptorStructure-Based Discovery of Allosteric Modulators of Two Related Class B G-Protein-Coupled Receptors
P2860
Q27687653-53EC169E-A460-436D-94B9-A4163155E151Q28476374-8C73AE56-0E55-4AAF-B81E-A704221AB7BFQ28477082-010FEE68-1AA7-4AAC-A236-72079AF69B09Q30368732-269E1BD2-CADD-4485-A0D2-D3767EB1ABA3Q30401802-FBA7C40B-AB61-4429-9682-9DBBA8FEACF7Q33911197-C69C81B9-7BBF-483F-B7F0-80C185FE7D3DQ34179174-C1C921CF-8FF8-424A-B928-D88C5D8F367EQ34623053-BB418F86-9ACA-455A-B281-012FF1C98136Q35158385-13C2306F-D8FA-45C5-A588-0E98252872ABQ35611767-4F8179A4-A3DB-4407-B7E0-1E46662282A3Q35834471-089506A9-81DA-4A60-A00A-84861B19C248Q35900688-08960A51-4240-497A-94DC-C0ED74102E06Q36497002-6670F051-6972-4295-B8EB-39F8A30847B2Q36513131-451C019A-D88D-4FF6-8005-BBA78DFA2EECQ37068652-E4A48BA5-CBB9-423A-819F-6EFA67367A7BQ37203610-0AB91AF1-439B-40FC-8DEA-CD3DB199E1A3Q37208197-901843C3-08C6-4722-8811-2440F0B2B407Q37421646-A554C16F-C18D-445B-8131-E3855EF3ECCDQ38318694-A785DA49-357F-42C9-9F1A-362D08081CA5Q39614815-FBCA9E87-1A7D-42C0-823A-8A24219355B7Q39817865-14EF3761-5EE8-4FB9-930F-0596545FC53DQ41049560-78A4DD03-4C9E-4193-9191-A79070A0E20AQ41455641-47E2AE6D-0C25-4B39-9293-98AB4EAA35C1Q41883243-61040196-3895-47A1-8110-E520EF8FA0A4Q42131239-EDE62676-7CBD-4444-B11B-49EF87903751Q42241635-731023B0-00C8-4F39-98EF-63BC6772549DQ42425022-801080B8-9BD1-4269-8F82-DDA2840B7ED7Q42503570-F8EA0BAD-DBF0-4B87-AEC0-1D77FDEA8927Q46213205-79B63CFE-60F9-4AB3-BCEF-E2FD788E44D3Q46890983-B38A98AD-02CF-4A05-9D4F-3AFCB91EE4CBQ48194197-63A2FED5-4116-4E4F-9560-ED47D59784A2Q56687985-FFD99EEE-470D-4E29-8479-1506279E2108Q56991394-1667AA89-09EB-4F15-8C4F-DD218F33300CQ56991997-D8ABEB0F-1BD2-4E7F-BB67-14F5A8C161A4
P2860
An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
An activation switch in the rh ...... ors: the thyrotropin receptor.
@en
An activation switch in the rh ...... ors: the thyrotropin receptor.
@nl
type
label
An activation switch in the rh ...... ors: the thyrotropin receptor.
@en
An activation switch in the rh ...... ors: the thyrotropin receptor.
@nl
prefLabel
An activation switch in the rh ...... ors: the thyrotropin receptor.
@en
An activation switch in the rh ...... ors: the thyrotropin receptor.
@nl
P2093
P2860
P356
P1476
An activation switch in the rh ...... ors: the thyrotropin receptor.
@en
P2093
Cedric Govaerts
Eneko Urizar
Gilbert Vassart
Sabine Costagliola
Sylvie Claeysen
Xavier Deupí
P2860
P304
17135-17141
P356
10.1074/JBC.M414678200
P407
P577
2005-02-18T00:00:00Z