Decreased neuronal nitric oxide synthase messenger RNA and somatostatin messenger RNA in the striatum of Huntington's disease.
about
Genetics and neuropathology of Huntington's diseaseStructure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthasePeripheral but crucial: A hydrophobic pocket (Tyr706, Leu337, and Met336) for potent and selective inhibition of neuronal nitric oxide synthasePotent, Highly Selective, and Orally Bioavailable Gem -Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide SynthaseImproved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide SynthaseCyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthaseIntramolecular hydrogen bonding: A potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthaseIn search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structuresChiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitorsSimplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase InhibitionAccessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase InhibitorsNitric Oxide Synthase Inhibitors That Interact with Both Heme Propionate and Tetrahydrobiopterin Show High Isoform SelectivityReview: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibitionDevelopment of urea and thiourea kynurenamine derivatives: synthesis, molecular modeling, and biological evaluation as nitric oxide synthase inhibitors.Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1.Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.Role of aberrant nitric oxide synthase-3 expression in cerebrovascular degeneration and vascular-mediated injury in Alzheimer's disease.Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.Nitric oxide and nitric oxide synthase in Huntington's disease.Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthaseRegulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease.Mechanism of Inactivation of Neuronal Nitric Oxide Synthase by (S)-2-Amino-5-(2-(methylthio)acetimidamido)pentanoic Acid.2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and SelectivityTranscriptional signatures in Huntington's disease.Targeted knock-down of neuronal nitric oxide synthase expression in basal forebrain with RNA interferenceMolecular mechanisms and potential therapeutical targets in Huntington's disease.Advances in huntington disease drug discovery: novel approaches to model disease phenotypes.Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF.Elucidating nitric oxide synthase domain interactions by molecular dynamics.TAK-063, a Novel Phosphodiesterase 10A Inhibitor, Protects from Striatal Neurodegeneration and Ameliorates Behavioral Deficits in the R6/2 Mouse Model of Huntington's Disease.Loss of hippocampal neuronal nitric oxide synthase contributes to the stress-related deficit in learning and memory.Different effect of chronic stress on learning and memory in BALB/c and C57BL/6 inbred mice: Involvement of hippocampal NO production and PKC activity.Somatostatin-immunoreactive senile plaque-like structures in the frontal cortex and nucleus accumbens of aged tree shrews and Japanese macaques.Disrupted striatal neuron inputs and outputs in Huntington's disease.
P2860
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P2860
Decreased neuronal nitric oxide synthase messenger RNA and somatostatin messenger RNA in the striatum of Huntington's disease.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Decreased neuronal nitric oxid ...... iatum of Huntington's disease.
@en
Decreased neuronal nitric oxid ...... iatum of Huntington's disease.
@nl
type
label
Decreased neuronal nitric oxid ...... iatum of Huntington's disease.
@en
Decreased neuronal nitric oxid ...... iatum of Huntington's disease.
@nl
prefLabel
Decreased neuronal nitric oxid ...... iatum of Huntington's disease.
@en
Decreased neuronal nitric oxid ...... iatum of Huntington's disease.
@nl
P2093
P1433
P1476
Decreased neuronal nitric oxid ...... iatum of Huntington's disease.
@en
P2093
P304
P356
10.1016/0306-4522(95)00596-X
P407
P577
1996-06-01T00:00:00Z