The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.
about
Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemiasHERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cellsStructural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbetaActivation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion proteinRoles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formationA novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cellsThe PEBP2betaMYH11 fusion created by Inv(16)(p13;q22) in myeloid leukemia impairs neutrophil maturation and contributes to granulocytic dysplasiaThe AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion proteinA Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesisThe inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressorETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complexCBFbeta is a facultative Runx partner in the sea urchin embryo.Stem Cell Modeling of Core Binding Factor Acute Myeloid LeukemiaSpecification and function of hemogenic endothelium during embryogenesisCore Binding Factor Acute Myeloid Leukemia: New Prognostic Categories and Therapeutic OpportunitiesAdenosine signaling promotes hematopoietic stem and progenitor cell emergence.Hematopoietic (stem) cell development - how divergent are the roads taken?Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8)Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1AML1 interconnected pathways of leukemogenesisCooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemiaInteractions between the leukaemia-associated ETO homologues of nuclear repressor proteinsThe RUNX genes: gain or loss of function in cancerHematopoietic Signaling Mechanism Revealed from a Stem/Progenitor Cell CistromeDimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradationFailure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOGThe interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiationCbfbeta interacts with Runx2 and has a critical role in bone developmentRunx1 function in hematopoiesis is required in cells that express TekMOZ is essential for maintenance of hematopoietic stem cellsThe core-binding factor beta subunit is required for bone formation and hematopoietic maturationMutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunitHematopoietic, angiogenic and eye defects in Meis1 mutant animals.Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factorSignificance of oncogenes and tumor suppressor genes in AML prognosis.Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia.Structure and Biophysics of CBFβ/RUNX and Its Translocation Products.Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1
P2860
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P2860
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.
@en
The CBFbeta subunit is essential for CBFalpha2
@nl
type
label
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.
@en
The CBFbeta subunit is essential for CBFalpha2
@nl
prefLabel
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.
@en
The CBFbeta subunit is essential for CBFalpha2
@nl
P2093
P1433
P1476
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo.
@en
P2093
Bushweller JH
Marín-Padilla M
P304
P356
10.1016/S0092-8674(00)81389-6
P407
P577
1996-11-01T00:00:00Z