The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
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The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signalingCdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiationThe Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolutionA small molecule that binds Hedgehog and blocks its signaling in human cellsEstablishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedbackHedgehog signaling and maintenance of homeostasis in the intestinal epitheliumCdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in miceThe mode of Hedgehog binding to Ihog homologues is not conserved across different phylaAll Mammalian Hedgehog Proteins Interact with Cell Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved MannerStructure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling.Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothenedA sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal responseGas1 extends the range of Hedgehog action by facilitating its signalingThe Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse developmentN-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblastsThe histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3.Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epitheliaCdon promotes neural crest migration by regulating N-cadherin localization.Smoothened goes molecular: new pieces in the hedgehog signaling puzzleDifferential screening identifies transcripts with depot-dependent expression in white adipose tissues.Genetic and biochemical definition of the Hedgehog receptor.Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.Hedgehog signaling in the normal and neoplastic mammary gland.Mechanism and evolution of cytosolic Hedgehog signal transductionCdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicleKinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway.Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium.Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptorsIhog and Boi are essential for Hedgehog signaling in Drosophila.Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligandCytonemes and the dispersion of morphogensDrosophila Boi limits Hedgehog levels to suppress follicle stem cell proliferation.New components of Drosophila leg development identified through genome wide association studiesDampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis.Proteoglycan interactions with Sonic Hedgehog specify mitogenic responsesBoc modifies the holoprosencephaly spectrum of Cdo mutant mice.Clinical implications of hedgehog signaling pathway inhibitorsApplications of high-throughput RNA interference screens to problems in cell and developmental biology.
P2860
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P2860
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
@en
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
@nl
type
label
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
@en
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
@nl
prefLabel
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
@en
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
@nl
P2093
P1433
P1476
The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.
@en
P2093
Lawrence Lum
Philip Beachy
Shenqin Yao
P304
P356
10.1016/J.CELL.2006.02.040
P407
P577
2006-04-01T00:00:00Z