A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation.
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The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcriptioncAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytesPhysical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-YModulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB and CREMDifferential activation of viral and cellular promoters by human T-cell lymphotropic virus-1 tax and cAMP-responsive element modulator isoformsTax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation.Human T-cell leukemia virus type 1 Tax requires direct access to DNA for recruitment of CREB binding protein to the viral promoterHuman T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.Suboptimal enhancer sequences are required for efficient bovine leukemia virus propagation in vivo: implications for viral latencyMolecular interactions involved in the transactivation of the human T-cell leukemia virus type 1 promoter mediated by Tax and CREB-2 (ATF-4).Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300The high-affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expressionDifferential requirements for activation of integrated and transiently transfected human T-cell leukemia virus type 1 long terminal repeatIdentification of a male-specific RNA binding protein that regulates sex-specific splicing of Bmdsx by increasing RNA binding activity of BmPSI.Human T cell leukemia virus type I and neurologic disease: events in bone marrow, peripheral blood, and central nervous system during normal immune surveillance and neuroinflammation.The CREB, ATF-1, and ATF-2 transcription factors from bovine leukemia virus-infected B lymphocytes activate viral expression.Function of the human T-cell leukemia virus type 1 21-base-pair repeats in basal transcriptionThe role of ATF in regulating the human cytomegalovirus DNA polymerase (UL54) promoter during viral infection.The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB.Transcriptional activation of RNA polymerase III-dependent genes by the human T-cell leukemia virus type 1 tax proteinComplex formation between CREB and Tax enhances the binding affinity of CREB for the human T-cell leukemia virus type 1 21-base-pair repeats.Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: a molecular mechanism of Tax transactivation.Genetic characterization of transactivation of the human T-cell leukemia virus type 1 promoter: Binding of Tax to Tax-responsive element 1 is mediated by the cyclic AMP-responsive members of the CREB/ATF family of transcription factorsThe oncoprotein Tax of the human T-cell leukemia virus type 1 activates transcription via interaction with cellular ATF-1/CREB factors in Saccharomyces cerevisiae.Identification of a human T-cell leukemia virus type I tax peptide in contact with DNA.The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove.Specific regions of contact between human T-cell leukemia virus type I Tax protein and DNA identified by photocross-linking.The fundamental ribosomal RNA transcription initiation factor-IB (TIF-IB, SL1, factor D) binds to the rRNA core promoter primarily by minor groove contacts.Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human T-cell leukemia virus type 1 is responsible for transcriptional activation by tax proteinStimulation of cyclin-dependent kinase activity and G1- to S-phase transition in human lymphocytes by the human T-cell leukemia/lymphotropic virus type 1 Tax protein.The human T-cell leukemia virus type 1 oncoprotein Tax inhibits the transcriptional activity of c-Myb through competition for the CREB binding protein.Immortalization of T lymphocytes by human T-cell leukemia virus type 1 is independent of the tax-CBP/p300 interactionImmortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone.In vivo genomic footprinting of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeat enhancer sequences in HTLV-1-infected human T-cell lines with different levels of Tax I activity.In vitro transcription of human T-cell leukemia virus type 1 is RNA polymerase II dependent.SR-related protein TAXREB803/SRL300 is an important cellular factor for the transactivational function of human T-cell lymphotropic virus type 1 Tax.T-cell receptor/CD28 engagement when combined with prostaglandin E2 treatment leads to potent activation of human T-cell leukemia virus type 1.Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control.Transcription factor binding and histone modifications on the integrated proviral promoter in human T-cell leukemia virus-I-infected T-cells.
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P2860
A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation.
@en
A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation.
@nl
type
label
A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation.
@en
A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation.
@nl
prefLabel
A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation.
@en
A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation.
@nl
P2093
P2860
P356
P1476
A molecular mechanism for human T-cell leukemia virus latency and Tax transactivation.
@en
P2093
P2860
P304
12814-12822
P356
10.1074/JBC.270.21.12814
P407
P577
1995-05-01T00:00:00Z