Structure-function relationships in the Na,K-ATPase alpha subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme.
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Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategyMutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS.ATP1A2 Mutations in Migraine: Seeing through the Facets of an Ion Pump onto the Neurobiology of DiseaseRegulation of the cardiac sodium pumpCrystal structure of the high-affinity Na+,K+-ATPase-ouabain complex with Mg2+ bound in the cation binding siteCrystal structure of Na+, K(+)-ATPase in the Na(+)-bound stateNa+/Ca2+ exchange and Na+/K+-ATPase in the heartThe alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heartThe highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulationCloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene familySodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal controlTo scale or not to scale: the principles of dose extrapolationMolecular dissection of functional domains of the E1E2-ATPase using sodium and calcium pump chimeric molecules.Ouabain- and Ca2(+)-sensitive ATPase activity of chimeric Na- and Ca-pump molecules.Stability of Na(+)-K(+)-ATPase alpha-subunit isoforms in evolution.Structure, transmembrane topology and helix packing of P-type ion pumps.Hyperpolarization-activated inward leakage currents caused by deletion or mutation of carboxy-terminal tyrosines of the Na+/K+-ATPase {alpha} subunitRegulation of Na,K-adenosine triphosphatase gene expression by sodium ions in cultured neonatal rat cardiocytes.Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance.The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ionsFunctional expression of the genomic DNA sequences encoding mouse Na,K-ATPase alpha 1 gene by cotransfection of overlapping genomic DNA segmentsThe carbohydrate moieties of the beta-subunit of Na+, K(+)-ATPase: their lateral motions and proximity to the cardiac glycoside site.Mutator suppression and escape from replication error-induced extinction in yeastThe sodium pump and hypertension: a physiological role for the cardiac glycoside binding site of the Na,K-ATPase.Na,K-ATPase in diabetic rat small intestine. Changes at protein and mRNA levels and role of glucagon.Structural similarities of Na,K-ATPase and SERCA, the Ca(2+)-ATPase of the sarcoplasmic reticulum.Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.Parallel molecular evolution in an herbivore communityConformational dynamics of the Na+/K+-ATPase probed by voltage clamp fluorometryAldosterone modulates sodium kinetics of Na,K-ATPase containing an alpha 1 subunit in A6 kidney cell epitheliaFXYD proteins stabilize Na,K-ATPase: amplification of specific phosphatidylserine-protein interactions.Ouabain affinity determining residues lie close to the Na/K pump ion pathway.Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complexDigoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activityHigh-affinity ouabain binding by a chimeric gastric H+,K+-ATPase containing transmembrane hairpins M3-M4 and M5-M6 of the alpha 1-subunit of rat Na+,K+-ATPase.Ouabain binding site in a functioning Na+/K+ ATPaseStructural insights into the binding of cardiac glycosides to the digitalis receptor revealed by solid-state NMRDecoding cell lineage from acquired mutations using arbitrary deep sequencing.Widespread convergence in toxin resistance by predictable molecular evolutionCommunity-wide convergent evolution in insect adaptation to toxic cardenolides by substitutions in the Na,K-ATPase.
P2860
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P2860
Structure-function relationships in the Na,K-ATPase alpha subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年学术文章
@wuu
1988年学术文章
@zh-cn
1988年学术文章
@zh-hans
1988年学术文章
@zh-my
1988年学术文章
@zh-sg
1988年學術文章
@yue
1988年學術文章
@zh
1988年學術文章
@zh-hant
name
Structure-function relationshi ...... es a ouabain-resistant enzyme.
@en
Structure-function relationshi ...... es a ouabain-resistant enzyme.
@nl
type
label
Structure-function relationshi ...... es a ouabain-resistant enzyme.
@en
Structure-function relationshi ...... es a ouabain-resistant enzyme.
@nl
prefLabel
Structure-function relationshi ...... es a ouabain-resistant enzyme.
@en
Structure-function relationshi ...... es a ouabain-resistant enzyme.
@nl
P356
P1433
P1476
Structure-function relationshi ...... es a ouabain-resistant enzyme.
@en
P2093
P304
P356
10.1021/BI00422A016
P407
P577
1988-11-01T00:00:00Z