Biological activity of recombinant factor VIII variants lacking the central B-domain and the heavy-chain sequence Lys713-Arg740: discordant in vitro and in vivo activity.
about
A1 subunit-mediated regulation of thrombin-activated factor VIII A2 subunit dissociation.Intracellular retention of a factor VIII protein with an Arg2307-->Gln mutation as a cause of haemophilia A.Characterization of des-(741-1668)-factor VIII, a single-chain factor VIII variant with a fusion site susceptible to proteolysis by thrombin and factor Xa.Low density lipoprotein receptor-related protein and factor IXa share structural requirements for binding to the A3 domain of coagulation factor VIII.Expression of human coagulation factor VIII in adipocytes transduced with the simian immunodeficiency virus agmTYO1-based vector for hemophilia A gene therapy.Intracellular accumulation of factor VIII induced by missense mutations Arg593-->Cys and Asn618-->Ser explains cross-reacting material-reduced haemophilia A.Use of denaturing gradient gel blots to screen for point mutations in the factor VIII gene.
P2860
Q34499164-0D853095-4B0D-4E29-BD14-8C14794F4624Q41167453-9239F81F-11B5-461D-8A4B-5429D5E02D4DQ41828726-677D0AC2-1028-49A3-908B-464DC1B390B5Q44274593-0E494B6E-0D3A-4D6E-86AC-49AE26EE4E0CQ45698003-C0B382F3-4563-4472-829D-A3D0822F586BQ45865538-9F6751F0-F3F1-4F7D-8DFA-1F80E8ACA7CCQ45890208-C139B561-354D-45F2-881E-CDBC47450DA9
P2860
Biological activity of recombinant factor VIII variants lacking the central B-domain and the heavy-chain sequence Lys713-Arg740: discordant in vitro and in vivo activity.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
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1993年學術文章
@zh-hant
name
Biological activity of recombi ...... in vitro and in vivo activity.
@en
Biological activity of recombi ...... in vitro and in vivo activity.
@nl
type
label
Biological activity of recombi ...... in vitro and in vivo activity.
@en
Biological activity of recombi ...... in vitro and in vivo activity.
@nl
prefLabel
Biological activity of recombi ...... in vitro and in vivo activity.
@en
Biological activity of recombi ...... in vitro and in vivo activity.
@nl
P2093
P2860
P1476
Biological activity of recombi ...... in vitro and in vivo activity.
@en
P2093
Klaasse Bos JM
Verbeet MP
de Keyzer-Nellen MJ
van Leen RW
van Mourik JA
P2860
P304
P356
10.1111/J.1365-2141.1993.TB08656.X
P407
P577
1993-09-01T00:00:00Z