In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.
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Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylaseBiochemical and structural characterization of mammalian-like purine nucleoside phosphorylase from the Archaeon Pyrococcus furiosus.Prodrug converting enzyme gene delivery by L. monocytogenes.Prodrug activation enzymes in cancer gene therapy.Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene.Antitumor activity of 2-fluoro-2'-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase.In situ gene therapy for prostate cancer: immunomodulatory approaches.Use of bacteria as anticancer agents.Gene therapy for malignant liver disease.Purine nucleoside phosphorylase targeted by annexin v to breast cancer vasculature for enzyme prodrug therapy.Cancer gene therapy.Gene therapy and targeted toxins for glioma.Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosidesMolecular architecture of E. coli purine nucleoside phosphorylase studied by analytical ultracentrifugation and CD spectroscopy.Development of gene therapy in association with clinically used cytotoxic deoxynucleoside analogues.PRE-CLINICAL AND CLINICAL VALIDATION OF AN ANTI-CANCER MODALITY THAT ABLATES REFRACTORY, LOW GROWTH FRACTION TUMORS.Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase.Regioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer.Prodrug-activating Gene Therapy with Rabbit Cytochrome P450 4B1/4-Ipomeanol or 2-Aminoanthracene System in Glioma Cells.Activators of viral gene expression in polarized epithelial monolayers identified by rapid-throughput drug screening.Design and evaluation of 5'-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant.Preclinical evaluation of a prostate-targeted gene-directed enzyme prodrug therapy delivered by ovine atadenovirus.Thermus thermophilus nucleoside phosphorylases active in the synthesis of nucleoside analogues.Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase.Palladium-catalyzed cross-coupling reactions in c6 modifications of purine nucleosides.Transcription-targeted gene therapy for androgen-independent prostate cancer.A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy.Gene therapy for prostate cancer delivered by ovine adenovirus and mediated by purine nucleoside phosphorylase and fludarabine in mouse models.Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase.Convenient syntheses of 6-methylpurine and related nucleosides.In vivo sensitization of ovarian tumors to chemotherapy by expression of E. coli purine nucleoside phosphorylase in a small fraction of cells.Synergistic antitumor efficacy of suicide/ePNP gene and 6-methylpurine 2'-deoxyriboside via Salmonella against murine tumors.Efficient Fludarabine-Activating PNP From Archaea as a Guidance for Redesign the Active Site of E. Coli PNP.Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex.Delivery of replication-competent retrovirus expressing Escherichia coli purine nucleoside phosphorylase increases the metabolism of the prodrug, fludarabine phosphate and suppresses the growth of bladder tumor xenografts.Gene therapy and targeted toxins for glioma
P2860
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P2860
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.
@en
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.
@nl
type
label
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.
@en
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.
@nl
prefLabel
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.
@en
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.
@nl
P2093
P1433
P1476
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase.
@en
P2093
E J Sorscher
G Y Gillespie
J A Montgomery
J A Secrist
K S Gilbert
L L Bennett
W B Parker
P304
P356
10.1089/HUM.1997.8.14-1637
P577
1997-09-01T00:00:00Z