Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats.
about
Novel α-MSH analog causes weight loss in obese rats and minipigs and improves insulin sensitivityDeletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesityModerate long-term modulation of neuropeptide Y in hypothalamic arcuate nucleus induces energy balance alterations in adult rats.Unraveling the genetics of human obesity.Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion.Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesitySimultaneous POMC gene transfer to hypothalamus and brainstem increases physical activity, lipolysis and reduces adult-onset obesity.The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Progress and prospects: gene therapy for performance and appearance enhancement.The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo.Pro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade.Intermittent MTII application evokes repeated anorexia and robust fat and weight loss.Lentivirus-mediated α-melanocyte-stimulating hormone overexpression in the hypothalamus decreases diet induced obesity in mice.Endogenous ACTH, not only alpha-melanocyte-stimulating hormone, reduces food intake mediated by hypothalamic mechanisms.Pituitary adenylate cyclase-activating polypeptide inhibits food intake in mice through activation of the hypothalamic melanocortin system.Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector.Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss.Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction.Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet.
P2860
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P2860
Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Hypothalamic pro-opiomelanocor ...... cose intolerance in aged rats.
@en
Hypothalamic pro-opiomelanocor ...... cose intolerance in aged rats.
@nl
type
label
Hypothalamic pro-opiomelanocor ...... cose intolerance in aged rats.
@en
Hypothalamic pro-opiomelanocor ...... cose intolerance in aged rats.
@nl
prefLabel
Hypothalamic pro-opiomelanocor ...... cose intolerance in aged rats.
@en
Hypothalamic pro-opiomelanocor ...... cose intolerance in aged rats.
@nl
P2093
P1433
P1476
Hypothalamic pro-opiomelanocor ...... cose intolerance in aged rats.
@en
P2093
P2860
P2888
P304
P356
10.1007/S00125-005-1943-8
P577
2005-10-05T00:00:00Z
P5875
P6179
1003971645