ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.
about
FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCLRemodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase.Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis.Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiaeSaccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates.Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.The yeast Pif1p DNA helicase preferentially unwinds RNA DNA substratesSrs2: the "Odd-Job Man" in DNA repair.Unwinding of synthetic replication and recombination substrates by Srs2.Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage.The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis.Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNAFunctional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption.Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.Srs2 prevents Rad51 filament formation by repetitive motion on DNA.Catalysis of strand annealing by replication protein A derives from its strand melting properties.Hmi1p from Saccharomyces cerevisiae mitochondria is a structure-specific DNA helicase.Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms.Multifunctional roles of Saccharomyces cerevisiae Srs2 protein in replication, recombination and repair.Roles of DNA helicases in the mediation and regulation of homologous recombination.A SRS2 homolog from Arabidopsis thaliana disrupts recombinogenic DNA intermediates and facilitates single strand annealing.Biochemical characterization of AtRECQ3 reveals significant differences relative to other RecQ helicases.Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein.Monitoring Replication Protein A (RPA) dynamics in homologous recombination through site-specific incorporation of non-canonical amino acids.Def1 and Dst1 play distinct roles in repair of AP lesions in highly transcribed genomic regions.Tight Regulation of Srs2 Helicase Activity Is Crucial for Proper Functioning of DNA Repair Mechanisms.The Main Role of Srs2 in DNA Repair Depends on Its Helicase Activity, Rather than on Its Interactions with PCNA or Rad51
P2860
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P2860
ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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name
ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.
@en
ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.
@nl
type
label
ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.
@en
ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.
@nl
prefLabel
ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.
@en
ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.
@nl
P2093
P2860
P356
P1476
ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.
@en
P2093
Mothe Sreedhar Reddy
Patrick Sung
Stephen Van Komen
P2860
P304
44331-44337
P356
10.1074/JBC.M307256200
P407
P577
2003-09-08T00:00:00Z