In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.
about
Advancing human health risk assessment: integrating recent advisory committee recommendationsThe vanishing zero revisited: thresholds in the age of genomics.The endogenous exposome.Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships.Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damageThe formation and biological significance of N7-guanine adductsDose-response assessment of four genotoxic chemicals in a combined mouse and rat micronucleus (MN) and Comet assay protocol.Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.Is nelfinavir exposure associated with cancer incidence in HIV-positive individuals?Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.Genotoxicity testing: moving beyond qualitative "screen and bin" approach towards characterization of dose-response and thresholds.The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance.Reproductive toxicants have a threshold of adversity.Need and potential value of the Pig-ain vivo mutation assay-a HESI perspective.Defining EMS and ENU dose-response relationships using the Pig-a mutation assay in ratsInternational regulatory requirements for genotoxicity testing for pharmaceuticals used in human medicine, and their impurities and metabolites.Acute dosing and p53-deficiency promote cellular sensitivity to DNA methylating agents.Dose-response relationship of temozolomide, determined by the Pig-a, comet, and micronucleus assay.Phenolphthalein induces centrosome amplification and tubulin depolymerization in vitro.Influence of DNA repair on nonlinear dose-responses for mutation.Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation.N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage.DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.Dose-Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU.Sublinear response in lacZ mutant frequency of Muta™ Mouse spermatogonial stem cells after low dose subchronic exposure to N-ethyl-N-nitrosourea.Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia.Refractory status epilepticus, serious rhabdomyolysis, acute liver injury, and pancytopenia after a massive intake of ethyl methanesulfonate: a case report.Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice.Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement.Quantitative assessment of the dose-response of alkylating agents in DNA repair proficient and deficient ames tester strains.BPDE-induced genotoxicity: relationship between DNA adducts, mutagenicity in the in vitro PIG-A assay, and the transcriptional response to DNA damage in TK6 cells.Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate.New approaches to advance the use of genetic toxicology analyses for human health risk assessment
P2860
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P2860
In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.
@en
In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.
@nl
type
label
In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.
@en
In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.
@nl
prefLabel
In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.
@en
In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.
@nl
P1433
P1476
In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.
@en
P2093
Elmar Gocke
Lutz Müller
P304
P356
10.1016/J.MRGENTOX.2009.04.005
P407
P577
2009-04-17T00:00:00Z