Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells.
about
A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 proteinPresenilin 1 associates with glycogen synthase kinase-3beta and its substrate tauMutations in presenilin 2 and its implications in Alzheimer's disease and other dementia-associated disordersPresenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-cateninPresenilin 1 protein directly interacts with Bcl-2Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyBiology of presenilins as causative molecules for Alzheimer disease.The role of cell cycle-mediated events in Alzheimer's disease.LDL receptor-related protein (LRP) in Alzheimer's disease: towards a unified theory of pathogenesis.Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons.Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively.Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial functionIncreased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I).Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster.Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.An upstream element containing an ETS binding site is crucial for transcription of the human presenilin-1 gene.The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis.Capacitative Ca2+ entry is involved in regulating soluble amyloid precursor protein (sAPPalpha) release mediated by muscarinic acetylcholine receptor activation in neuroblastoma SH-SY5Y cells.Mutant nicastrin protein can induce the cytochrome c release and the Bax expression.Presenilin overexpression arrests cells in the G1 phase of the cell cycle. Arrest potentiated by the Alzheimer's disease PS2(N141I)mutant.Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals.Apoptosis, neurotrophic factors and neurodegeneration.Fibroblast growth factor rescues brain endothelial cells lacking presenilin 1 from apoptotic cell death following serum starvation.Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation.Localization and possible functions of presenilins in brain.A unifying hypothesis of Alzheimer's disease. III. Risk factors.Androgen receptor overexpression is neuroprotective in experimental stroke.Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.
P2860
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P2860
Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Alzheimer-associated presenili ...... ty to apoptosis in PC12 cells.
@en
Alzheimer-associated presenili ...... ty to apoptosis in PC12 cells.
@nl
type
label
Alzheimer-associated presenili ...... ty to apoptosis in PC12 cells.
@en
Alzheimer-associated presenili ...... ty to apoptosis in PC12 cells.
@nl
prefLabel
Alzheimer-associated presenili ...... ty to apoptosis in PC12 cells.
@en
Alzheimer-associated presenili ...... ty to apoptosis in PC12 cells.
@nl
P2860
P1433
P1476
Alzheimer-associated presenili ...... ty to apoptosis in PC12 cells.
@en
P2093
P2860
P356
10.1016/S0014-5793(96)01142-8
P407
P577
1996-11-01T00:00:00Z