Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

Item
http://www.wikidata.org/entity/Q46217563
New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity.Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.A molecular model of CYP2D6 constructed by homology with the CYP2C5 crystallographic template: investigation of enzyme-substrate interactions.
P2860

Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.

Item
http://www.wikidata.org/entity/Q46217563
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
Active-site topologies of huma ...... paragine, and glycine mutants.
@en
Active-site topologies of huma ...... paragine, and glycine mutants.
@nl
type
label
Active-site topologies of huma ...... paragine, and glycine mutants.
@en
Active-site topologies of huma ...... paragine, and glycine mutants.
@nl
prefLabel
Active-site topologies of huma ...... paragine, and glycine mutants.
@en
Active-site topologies of huma ...... paragine, and glycine mutants.
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698
P356
P1433
P1476
Active-site topologies of huma ...... sparagine, and glycine mutants
@en
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P698