about
Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines.Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCRCytochrome P450 CYP2D6.Science, medicine, and the future: Pharmacogenetics.Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases.Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-ultraviolet A (PUVA) sensitivity.The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms.Regulation of cytochrome P450 gene expression in human colon and breast tumour xenograftsRecurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal CancerIndividuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancerGenetic variants in XRCC2: new insights into colorectal cancer tumorigenesisABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells.Characterization of a human keratinocyte HaCaT cell line model to study the regulation of CYP2S1.Metabolic polymorphisms and cancer susceptibility.Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)Evidence that aspartic acid 301 is a critical substrate-contact residue in the active site of cytochrome P450 2D6.Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk.A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer.Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.Quantitative real-time reverse transcription-polymerase chain reaction analysis of drug metabolizing and cytoprotective genes in psoriasis and regulation by ultraviolet radiation.Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.Vegetable, fruit and meat consumption and potential risk modifying genes in relation to colorectal cancer.Active-site topologies of human CYP2D6 and its aspartate-301 --> glutamate, asparagine, and glycine mutants.Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy.A splice site polymorphism in the G-protein beta subunit influences antidepressant efficacy in depression.Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations.Melanocortin 1 receptor (MC1R) genotype influences erythemal sensitivity to psoralen-ultraviolet A photochemotherapy.Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer.Regulation of cutaneous drug-metabolizing enzymes and cytoprotective gene expression by topical drugs in human skin in vivo.Genetic factors associated with the aetiology and treatment of colorectal cancerGlutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapyCan dietary furanocoumarin ingestion enhance the erythemal response during high-dose UVA1 therapy?A comparative pharmacokinetic study of PARP inhibitors demonstrates favorable properties for niraparib efficacy in preclinical tumor modelsPharmacogeneticsChromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utilityGlutathione S-transferase M1 (GSTM1) genotype but not GSTT1 or MC1R genotype influences erythemal sensitivity to narrow band (TL-01) UVB phototherapy
P50
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P50
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researcher
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wetenschapper
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հետազոտող
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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Gillian Smith
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