Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia.
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Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology.Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping.Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs.Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core.Positive allosteric modulation of M1 and M4 muscarinic receptors as potential therapeutic treatments for schizophrenia.Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides.
P2860
Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
Discovery of VU0467485/AZ13713 ...... he Treatment of Schizophrenia.
@en
Discovery of VU0467485/AZ13713 ...... he Treatment of Schizophrenia.
@nl
type
label
Discovery of VU0467485/AZ13713 ...... he Treatment of Schizophrenia.
@en
Discovery of VU0467485/AZ13713 ...... he Treatment of Schizophrenia.
@nl
prefLabel
Discovery of VU0467485/AZ13713 ...... he Treatment of Schizophrenia.
@en
Discovery of VU0467485/AZ13713 ...... he Treatment of Schizophrenia.
@nl
P2093
P2860
P50
P1476
Discovery of VU0467485/AZ13713 ...... he Treatment of Schizophrenia.
@en
P2093
Alice L Rodriguez
Anna L Blobaum
Atin Lamsal
Bruce J Melancon
Carrie K Jones
Darren W Engers
Kellie D Nance
Mark E Duggan
Meredith J Noetzel
Michael Bubser
P2860
P304
P356
10.1021/ACSMEDCHEMLETT.6B00461
P577
2016-12-16T00:00:00Z