Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core.

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Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

@wuu

2017年学术文章

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2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

@zh-my

2017年学术文章

@zh-sg

2017年學術文章

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2017年學術文章

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name

Discovery of a novel, CNS pene ...... quinoline-3-carbonitrile core.

@en

Discovery of a novel, CNS pene ...... quinoline-3-carbonitrile core.

@nl

type

Item

label

Discovery of a novel, CNS pene ...... quinoline-3-carbonitrile core.

@en

Discovery of a novel, CNS pene ...... quinoline-3-carbonitrile core.

@nl

prefLabel

Discovery of a novel, CNS pene ...... quinoline-3-carbonitrile core.

@en

Discovery of a novel, CNS pene ...... quinoline-3-carbonitrile core.

@nl

P1476

Discovery of a novel, CNS pene ...... quinoline-3-carbonitrile core.

@en

P2093

Alice L Rodriguez

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Blake R Bewley

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Darren W Engers

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Hyekyung P Cho

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Paul K Spearing

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Rebecca L Weiner

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Sichen Chang

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Thomas M Bridges

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Vincent B Luscombe

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Xiaoyan Zhan

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P2860

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.

Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

The antipsychotic potential of muscarinic allosteric modulation

Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.

Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100

Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia

Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties

Allosteric antipsychotics: m4 muscarinic potentiators as novel treatments for schizophrenia

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)

Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.

P304

4274-4279

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P31

scholarly article

P356

10.1016/J.BMCL.2017.08.043

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

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P50

Colleen M. Niswender

Craig W. Lindsley

P Jeffrey Conn

P577

2017-08-20T00:00:00Z

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P698

28866269

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P932

5688877

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