Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat.
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Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.Detection of PIGO-deficient cells using proaerolysin: a valuable tool to investigate mechanisms of mutagenesis in the DT40 cell systemSimple monitoring of gene targeting efficiency in human somatic cell lines using the PIGA gene.Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples.Comparison of male versus female responses in the Pig-a mutation assay.Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethaneEfficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats.New and emerging technologies for genetic toxicity testing.In vivo pig-a and micronucleus study of the prototypical aneugen vinblastine sulfate.Applying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation.The in vitro PIG-A gene mutation assay: mutagenicity testing via flow cytometry based on the glycosylphosphatidylinositol (GPI) status of TK6 cells.In Vivo Pig-a gene mutation assay: Guidance for 3Rs-friendly implementation.The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review.Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays.Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol.When pigs fly: immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis.Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays.The frequency of Pig-a mutant red blood cells in rats exposed in utero to N-ethyl-N-nitrosourea.Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells.Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone.Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes.International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea.Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice.Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate.Detection of In Vivo Mutation in the Pig-a Gene of Mouse Bone Marrow Erythroids.Continued progress in developing the Pig-a gene mutation assay.CD48-deficient T-lymphocytes from DMBA-treated rats have de novo mutations in the endogenous Pig-a gene.Evaluation of the in vivo mutagenicity of isopropyl methanesulfonate in acute and 28-day studies.The in vivo Pig-a gene mutation assay is useful for evaluating the genotoxicity of ionizing radiation in mice.Manifestation and persistence of Pig-a mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea.In Vivo Rat T-Lymphocyte Pig-a Assay: Detection and Expansion of Cells Deficient in the GPI-Anchored CD48 Surface Marker for Analysis of Mutation in the Endogenous Pig-a Gene.Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.
P2860
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P2860
Development of an in vivo gene mutation assay using the endogenous Pig-A gene: I. Flow cytometric detection of CD59-negative peripheral red blood cells and CD48-negative spleen T-cells from the rat.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Development of an in vivo gene ...... e spleen T-cells from the rat.
@en
Development of an in vivo gene ...... e spleen T-cells from the rat.
@nl
type
label
Development of an in vivo gene ...... e spleen T-cells from the rat.
@en
Development of an in vivo gene ...... e spleen T-cells from the rat.
@nl
prefLabel
Development of an in vivo gene ...... e spleen T-cells from the rat.
@en
Development of an in vivo gene ...... e spleen T-cells from the rat.
@nl
P2093
P356
P1476
Development of an in vivo gene ...... e spleen T-cells from the rat.
@en
P2093
Daishiro Miura
Robert H Heflich
Vasily N Dobrovolsky
Yasuhiro Katsuura
Yoshinori Kasahara
P2860
P304
P356
10.1002/EM.20414
P577
2008-10-01T00:00:00Z