International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea. - Wikidata - awgldk - TriplyDB

International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea.

International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea.

http://www.wikidata.org/entity/Q46098496

about

Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples.Comparison of male versus female responses in the Pig-a mutation assay.Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate.Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethane Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens.Applying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation.Development of an in vitro PIG-A gene mutation assay in human cells.Comparison of integrated genotoxicity endpoints in rats after acute and subchronic oral doses of 4-nitroquinoline-1-oxide.Influence of DNA repair on nonlinear dose-responses for mutation.Dose-Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU.Characterisation of an in vivo Pig-a gene mutation assay for use in regulatory toxicology studies.Sublinear response in lacZ mutant frequency of Muta™ Mouse spermatogonial stem cells after low dose subchronic exposure to N-ethyl-N-nitrosourea.Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia.Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays.Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide.Quantitative assessment of the dose-response of alkylating agents in DNA repair proficient and deficient ames tester strains.Evaluation of the in vivo mutagenicity of isopropyl methanesulfonate in acute and 28-day studies.Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate.Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.

P2860

Q35400183-8E1B5BD3-444A-4A60-ACDA-61001CA3AEB5 Q35528022-8D152422-9343-4DDE-B6AC-10DB787BF535 Q35578148-CF6FE214-6EDA-4802-9775-0C8EEA8B7951 Q35578151-90BAED7F-1F27-43A3-A862-C858E543B617 Q35862975-09807248-88B8-4481-905B-0D961496F344 Q36400845-06F5AB5C-4EC8-4A02-A7C1-046E4146030D Q37346788-3921B7EC-EC68-46EC-A2E2-E15118C4BEF0 Q38676314-E2A998A7-94D5-4357-8CF0-D48F6079D8F6 Q38722763-AAA9627B-68CF-4C78-9FDC-C47499B4B210 Q38960044-E9F1BCA5-A8F5-46AF-BBD1-93F35A79D7BA Q39216690-99204FC5-DA1A-4C24-9AE5-9381E646536C Q40872489-8DD5B9CF-E46B-452A-A194-00DAF8313235 Q41437756-B65E01C9-FB85-4772-BC18-920EB3B3F8DF Q41566029-E579E192-A87F-4713-83DE-CF5AADA48A82 Q42101489-3C99AC8E-FDE9-47A1-B1AC-0B04B4BEE43E Q42708998-6C2F48CE-419F-4F4B-9354-D4103C2212E6 Q44505804-9ED97E8D-2044-4F97-BA2E-CF5A1E1CAEE7 Q46967734-E33F7AF5-9A93-4BB5-B6F6-1C4A594D0796 Q50460175-1937F762-B135-41D4-A343-4BAA63ED9C6E Q50477771-46964997-7995-4910-ACE6-692A281CC080 Q53142660-BCA3281E-FD39-463D-92A3-3524BC775100

P2860

International Pig-a gene mutation assay trial (stage III): results with N-methyl-N-nitrosourea.

http://www.wikidata.org/entity/Q46098496

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年学术文章

@wuu

2011年学术文章

@zh

2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

2011年學術文章

@zh-hant

name

International Pig-a gene mutat ...... s with N-methyl-N-nitrosourea.

@en

International Pig-a gene mutation assay trial

@nl

type

label

International Pig-a gene mutat ...... s with N-methyl-N-nitrosourea.

@en

International Pig-a gene mutation assay trial

@nl

prefLabel

International Pig-a gene mutat ...... s with N-methyl-N-nitrosourea.

@en

International Pig-a gene mutation assay trial

@nl

P1433

Q46098496-EDF7AE99-217B-4F35-B92E-25C4E722FBEC

P1476

Q46098496-94380D3F-CBE9-4567-B620-FF32E5CA518F

P2093

Q46098496-07546F17-322A-45EA-B46A-35A8D0BB6D56

Q46098496-24659EA6-7321-4A01-A767-3B72731A23FF

Q46098496-33E0C2DE-87EA-40FD-9590-7522A6F95B17

Q46098496-65429F7D-9057-4DF1-8847-A41F31D1FB20

Q46098496-6FAE0904-7753-4EAE-9609-6C6E8ADFED7F

Q46098496-F5AF4FAC-A3CD-489C-B0F3-C7AAA2837684

Q46098496-F6EBE5F2-14AC-49B9-8BB6-3008A173C8E6

P2860

Q46098496-07BF339E-8D2E-4787-BE70-89D9071B6FF9

Q46098496-08AE27F5-D14B-41DF-9A22-E785B4CA50F9

Q46098496-1468FC24-B472-498B-81A9-DC50AC094920

Q46098496-1C4B323E-1F79-4AC3-9AA6-FB463AC71030

Q46098496-26767CBF-B84C-44DC-BCE8-4A9186843340

Q46098496-3908E70C-83DE-4B8A-8A39-D2C0419BD8B1

Q46098496-41C6E33C-06A8-4B5A-AACB-5EE71C0EF58C

Q46098496-50FF85A0-C2FF-43E0-B0A5-5477A0BA5345

Q46098496-53CA187B-87A0-4721-8DF6-9902992F3FCB

Q46098496-54DDD20C-9F69-44C1-B509-74F5525DDACE

P304

Q46098496-8C39972D-2BA2-4EAA-B253-E6FA2A85BC9E

P31

Q46098496-21D15376-CE85-45AD-8AB8-31C29363CA30

P356

Q46098496-306B440F-AE36-43C9-B9B4-216E660E133C

P433

Q46098496-A14EA412-25C1-42A5-BF5D-3069D15806CF

P478

Q46098496-4A5E8D7B-FA92-4CA0-A357-85AB2EA9C942

P577

Q46098496-7CD1E2A8-38CF-4764-8E17-218C739D2BF3

P698

Q46098496-05F70081-B1A1-4C04-8534-2E5D776A30B8

P356

P1433

Environmental and Molecular Mutagenesis

P1476

International Pig-a gene mutat ...... s with N-methyl-N-nitrosourea.

@en

P2093

Amanda Giddings

http://www.w3.org/2001/XMLSchema#string

Andrew Henwood

http://www.w3.org/2001/XMLSchema#string

Anthony M Lynch

http://www.w3.org/2001/XMLSchema#string

Carol Gleason

http://www.w3.org/2001/XMLSchema#string

Julia Kenny

http://www.w3.org/2001/XMLSchema#string

Laura Custer

http://www.w3.org/2001/XMLSchema#string

Mike Aylott

http://www.w3.org/2001/XMLSchema#string

P2860

Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.

Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.

New and emerging technologies for genetic toxicity testing.

Need and potential value of the Pig-ain vivo mutation assay-a HESI perspective.

When pigs fly: immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis.

Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood.

The in vivo Pig-a gene mutation assay, a potential tool for regulatory safety assessment.

Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy.

Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens III. Appropriate follow-up testing in vivo.

Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea.

P304

699-710

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1002/EM.20691

http://www.w3.org/2001/XMLSchema#string

P433

9

http://www.w3.org/2001/XMLSchema#string

P478

52

http://www.w3.org/2001/XMLSchema#string

P577

2011-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

22167885

http://www.w3.org/2001/XMLSchema#string