Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors.
about
Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formationMolecular mechanisms promoting the pathogenesis of Schwann cell neoplasmsThe ErbB inhibitors trastuzumab and erlotinib inhibit growth of vestibular schwannoma xenografts in nude mice: a preliminary studyA liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serumA genetic screen for anchorage-independent proliferation in mammalian cells identifies a membrane-bound neuregulin.Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injuryTamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent mannerERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibromaBNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells.Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.Genetically engineered mouse models shed new light on the pathogenesis of neurofibromatosis type I-related neoplasms of the peripheral nervous system.Combinatorial therapy with tamoxifen and trifluoperazine effectively inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades.MicroRNA Expression Profile of Neural Progenitor-Like Cells Derived from Rat Bone Marrow Mesenchymal Stem Cells under the Influence of IGF-1, bFGF and EGF.The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in malignant peripheral nerve sheath tumor cellsMalignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands.Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesisThe Challenge of Cancer Genomics in Rare Nervous System Neoplasms: Malignant Peripheral Nerve Sheath Tumors as a Paradigm for Cross-Species Comparative Oncogenomics.Frequent EGFR Positivity and Overexpression in High-Grade Areas of Human MPNSTsHow does the Schwann cell lineage form tumors in NF1?EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy.Neuregulin-1 beta and neuregulin-1 alpha differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells.Suppression of proliferation of two independent NF1 malignant peripheral nerve sheath tumor cell lines by the pan-ErbB inhibitor CI-1033.Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis.Constitutive activation of neuregulin/ERBB3 signaling pathway in clear cell sarcoma of soft tissue.BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells4-Hydroxytamoxifen induces autophagic death through K-Ras degradation.The coexistence of peripheral nerve sheath tumors and vitiligo: more than coincidence?Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130/ STAT3 Signaling.Postinjury Induction of Activated ErbB2 Selectively Hyperactivates Denervated Schwann Cells and Promotes Robust Dorsal Root Axon Regeneration.Factors Within the Endoneurial Microenvironment Act to Suppress Tumorigenesis of MPNST
P2860
Q28752378-35ABFDA3-5D82-401C-83CC-01949EBB277BQ30457681-818E8631-A5BB-4C3D-943F-01BBBEAF76E8Q30487287-79639C94-80CB-496D-917E-500D1A519101Q33441373-685DC4D8-7771-41D5-9272-D4129C509920Q33644471-DC95CAE9-32BB-44DF-8A96-A235582A7271Q33647461-8FB73D4B-89C7-4394-A8FC-E3DD645A2757Q33746249-9A8219C2-7973-4DE6-8907-6B76AC592EB2Q33772914-5D3370E1-7A27-4ED6-823B-A565BD48340DQ33826589-B9F0A2E5-593C-4410-97D0-8DBF92B5DBCBQ35088274-234672CD-A587-46DE-AFAB-778F47EF0472Q35168073-84146161-5868-4B7D-94C2-03124A842595Q35612406-E0490D83-7EE2-4B2F-BF87-CAFDAB7ACEB2Q35686940-BDC6F67D-794B-4569-B477-4B4D118BA6BBQ35690166-95D1E052-DCDB-45E6-AC3B-EC562CC3723CQ35722985-711F8D7E-F42A-4D38-A8A0-FC1E4A0093FAQ35760676-8AD89FD8-9CEF-4B4C-9B41-62E36378FCEDQ36630091-B02983D9-84C2-4CAB-84EF-AE94C6ECC791Q36651930-4CEB5DFF-89BF-4271-A962-E415DFDE136FQ36753692-148C0DB1-8E86-4298-B45B-CE271B8C9831Q36853345-C1FC6977-01FD-4CD7-9027-4141E78FC43EQ37120518-A23B3388-D7AF-4B8B-9D5C-F6CA6E274376Q37284362-254D8D2C-821D-41EB-AFCC-B5DCADE1C8EEQ37348865-22A3AFF7-836A-4DDF-8D06-A992CA932A15Q37582080-BE2DE904-B582-4CA5-970B-AD631F57A456Q37722550-A7CA235D-C142-49C7-B69E-F945904B13D1Q38581899-C12BB1D3-B855-49F0-982E-D7BDBEE1EA78Q39038331-976C5FF6-2904-4C2D-B059-12FFF5199DD3Q39145600-04E41B82-A87F-4C1A-B0F2-D5B85FAF503AQ41096492-164D96F6-E254-46FA-9010-DF2092820E87Q42698939-E9850669-A73B-4193-A459-F9ED03411E84Q47618656-CFE45097-9886-4B49-B065-E726794F33C2Q58572678-9A057B12-441B-4FDC-9D6C-F04BA0EF269B
P2860
Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Activation of the neuregulin-1 ...... eripheral nerve sheath tumors.
@en
Activation of the neuregulin-1 ...... eripheral nerve sheath tumors.
@nl
type
label
Activation of the neuregulin-1 ...... eripheral nerve sheath tumors.
@en
Activation of the neuregulin-1 ...... eripheral nerve sheath tumors.
@nl
prefLabel
Activation of the neuregulin-1 ...... eripheral nerve sheath tumors.
@en
Activation of the neuregulin-1 ...... eripheral nerve sheath tumors.
@nl
P2860
P356
P1433
P1476
Activation of the neuregulin-1 ...... peripheral nerve sheath tumors
@en
P2093
Stephanie J Byer
William E Grizzle
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208730
P407
P577
2005-08-01T00:00:00Z