Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation. - Wikidata - awgldk - TriplyDB

Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.

Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.

http://www.wikidata.org/entity/Q46516143

about

Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives Integrative systems biology approaches in asthma pharmacogenomics Inhibition of human arginase I by substrate and product analogues 2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I Binding of α,α-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.Identification of differentially expressed proteins in blood plasma of control and cigarette smoke-exposed mice by 2-D DIGE/MS.Roles of arginase variants, atopy, and ozone in childhood asthma.Multitracer stable isotope quantification of arginase and nitric oxide synthase activity in a mouse model of pseudomonas lung infection.A physiologic and biochemical profile of clinically rejected lungs on a normothermic ex vivo lung perfusion platform.Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma Regulatory haplotypes in ARG1 are associated with altered bronchodilator response.Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation.Modulation of the oscillatory mechanics of lung tissue and the oxidative stress response induced by arginase inhibition in a chronic allergic inflammation model.Recent advances in arginine metabolism: roles and regulation of the arginases.Protein S-nitrosylation in health and disease: a current perspective.Effect of arginase inhibition on pulmonary L-arginine metabolism in murine Pseudomonas pneumonia Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.Macrophage heterogeneity in respiratory diseases.Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.Update in asthma 2008.Genetic predictors of response to therapy in childhood asthma.Aminoboronic acids and esters: from synthetic challenges to the discovery of unique classes of enzyme inhibitors.Role of arginase in asthma: potential clinical applications.Genetic basis for personalized medicine in asthma.Pathophysiology of tobacco smoke exposure: recent insights from comparative and redox proteomics.Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8.Fenretinide prevents inflammation and airway hyperresponsiveness in a mouse model of allergic asthma.Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.Role of arginase in impairing relaxation of lung parenchyma of hyperoxia-exposed neonatal rats.Arginine deficiency augments inflammatory mediator production by airway epithelial cells in vitro.Nitric oxide in asthma physiopathology.Free radical-producing myeloid-derived regulatory cells: potent activators and suppressors of lung inflammation and airway hyperresponsiveness Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?Arginase and arginine dysregulation in asthma.l-Arginine administration attenuates airway inflammation by altering l-arginine metabolism in an NC/Nga mouse model of asthma.Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.

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P2860

Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.

http://www.wikidata.org/entity/Q46516143

description

2008 nî lūn-bûn

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name

Arginase inhibition protects a ...... ponsiveness, and inflammation.

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Arginase inhibition protects a ...... ponsiveness, and inflammation.

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American Journal of Respiratory and Critical Care Medicine

P1476

Arginase inhibition protects a ...... ponsiveness, and inflammation.

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P2093

Annet B Zuidhof

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Harm Maarsingh

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Herman Meurs

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I Sophie T Bos

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Jean-Luc Boucher

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Johan Zaagsma

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Marcel van Duin

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P2860

Arginine metabolism: nitric oxide and beyond

Arginase attenuates inhibitory nonadrenergic noncholinergic nerve-induced nitric oxide generation and airway smooth muscle relaxation

Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma

Role of nitric oxide and superoxide in allergen-induced airway hyperreactivity after the late asthmatic reaction in guinea-pigs

Arginase and pulmonary diseases

Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts

Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization.

Almost all about citrulline in mammals.

Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthma

Genetic polymorphisms in arginase I and II and childhood asthma and atopy

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565-573

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10.1164/RCCM.200710-1588OC

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6

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178

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18583571

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