A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes.
about
Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125Small-molecule kinase inhibitors provide insight into Mps1 cell cycle functionScaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK InhibitorsStructure-Based Design of Orally Bioavailable 1 H -Pyrrolo[3,2- c ]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)In-silico modeling of the mitotic spindle assembly checkpointChemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosisCharacterization of a putative spindle assembly checkpoint kinase Mps1, suggests its involvement in cell division, morphogenesis and oxidative stress tolerance in Candida albicansPlx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores.TagSmart: analysis and visualization for yeast mutant fitness data measured by tag microarrays.Combination chemical geneticsThe MPS1 family of protein kinases.N-terminal regions of Mps1 kinase determine functional bifurcation.High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversineCompound prioritization methods increase rates of chemical probe discovery in model organisms.Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs.The interplay between chromosome stability and cell cycle control explored through gene-gene interaction and computational simulationA survey of yeast genomic assays for drug and target discovery.A chemical tool box defines mitotic and interphase roles for Mps1 kinase.The essential role of the CopN protein in Chlamydia pneumoniae intracellular growthMonitoring the fidelity of mitotic chromosome segregation by the spindle assembly checkpoint.Mitosis as an anti-cancer drug target.Targeting mitotic pathways for endocrine-related cancer therapeutics.Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715.Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores.Mitotic Kinases and p53 Signaling.Effective killing of the human pathogen Candida albicans by a specific inhibitor of non-essential mitotic kinesin Kip1p.Targeting the cell cycle in esophageal adenocarcinoma: an adjunct to anticancer treatment
P2860
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P2860
A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
A small-molecule inhibitor of ...... ension on mitotic chromosomes.
@en
A small-molecule inhibitor of ...... ension on mitotic chromosomes.
@nl
type
label
A small-molecule inhibitor of ...... ension on mitotic chromosomes.
@en
A small-molecule inhibitor of ...... ension on mitotic chromosomes.
@nl
prefLabel
A small-molecule inhibitor of ...... ension on mitotic chromosomes.
@en
A small-molecule inhibitor of ...... ension on mitotic chromosomes.
@nl
P2093
P1433
P1476
A small-molecule inhibitor of ...... ension on mitotic chromosomes.
@en
P2093
Andrew W Murray
John A Tallarico
Russell K Dorer
Sheng Zhong
Timothy J Mitchison
Wing Hung Wong
P304
P356
10.1016/J.CUB.2005.05.020
P407
P577
2005-06-01T00:00:00Z