Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I.
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Integrating TRPV1 Receptor Function with Capsaicin PsychophysicsBiophysical characterization of the isolated C-terminal region of the transient receptor potential vanilloid 1A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopyThermosensitive TRP channel pore turret is part of the temperature activation pathway.Forward genetic analysis reveals multiple gating mechanisms of TRPV4Conservation of tubulin-binding sequences in TRPV1 throughout evolution.Polymorphisms in TRPV1 and TAS2Rs associate with sensations from sampled ethanol.Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) proteinThe transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin.L596-W733 bond between the start of the S4-S5 linker and the TRP box stabilizes the closed state of TRPV4 channel.Modality-specific mechanisms of protein kinase C-induced hypersensitivity of TRPV1: S800 is a polymodal sensitization site.A combined coarse-grained and all-atom simulation of TRPV1 channel gating and heat activationHeteromeric heat-sensitive transient receptor potential channels exhibit distinct temperature and chemical responseMeasurement of Ensemble TRPV1 Ion Channel Currents Using Droplet Bilayers.Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?Coarse architecture of the transient receptor potential vanilloid 1 (TRPV1) ion channel determined by fluorescence resonance energy transferCarboxyl-terminal domain of transient receptor potential vanilloid 1 contains distinct segments differentially involved in capsaicin- and heat-induced desensitization.New strategies to develop novel pain therapies: addressing thermoreceptors from different points of view.A structural view of ligand-dependent activation in thermoTRP channels.Sensory TRP channels: the key transducers of nociception and pain.Role of the transient receptor potential vanilloid 5 (TRPV5) protein N terminus in channel activity, tetramerization, and trafficking.Versatile Roles of Intracellularly Located TRPV1 Channel.Toward elucidating the heat activation mechanism of the TRPV1 channel gating by molecular dynamics simulation.Side chain flexibility and coupling between the S4-S5 linker and the TRP domain in thermo-sensitive TRP channels: Insights from protein modeling.Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists.Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.Role of the transient receptor potential vanilloid 1 in inflammation and sepsisNovel methodology to identify TRPV1 antagonists independent of capsaicin activation.Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating.Mutation of I696 and W697 in the TRP box of vanilloid receptor subtype I modulates allosteric channel activation.The region adjacent to the C-end of the inner gate in transient receptor potential melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation.Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids
P2860
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P2860
Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I.
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2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
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@zh-hans
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name
Identification of molecular de ...... l box of vanilloid receptor I.
@en
Identification of molecular de ...... l box of vanilloid receptor I.
@nl
type
label
Identification of molecular de ...... l box of vanilloid receptor I.
@en
Identification of molecular de ...... l box of vanilloid receptor I.
@nl
prefLabel
Identification of molecular de ...... l box of vanilloid receptor I.
@en
Identification of molecular de ...... l box of vanilloid receptor I.
@nl
P2093
P356
P1433
P1476
Identification of molecular de ...... l box of vanilloid receptor I.
@en
P2093
Antonio Ferrer-Montiel
Asia Fernández-Carvajal
Carlos Belmonte
Gregorio Fernández-Ballester
Nuria García-Sanz
Pierluigi Valente
P304
P356
10.1096/FJ.08-107425
P407
P577
2008-06-16T00:00:00Z