CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.
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Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pupsTargeting xenobiotic receptors PXR and CAR in human diseasesNuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubulesEffect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers.Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasisClinical application of transcriptional activators of bile salt transporters.Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.Helicobacter hepaticus infection promotes hepatitis and preneoplastic foci in farnesoid X receptor (FXR) deficient mice.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Pregnane X receptor-mediated induction of Cyp3a by black cohosh.Impairment of bilirubin clearance and intestinal interleukin-6 expression in bile duct-ligated vitamin D receptor null miceHelicobacter hepaticus--induced liver tumor promotion is associated with increased serum bile acid and a persistent microbial-induced immune response.Deficiency of Capicua disrupts bile acid homeostasis.Swertianlarin, isolated from Swertia mussotii Franch, increases detoxification enzymes and efflux transporters expression in rats.Oral administration of oleanolic acid, isolated from Swertia mussotii Franch, attenuates liver injury, inflammation, and cholestasis in bile duct-ligated rats.Differences in the disposition of silymarin between patients with nonalcoholic fatty liver disease and chronic hepatitis C.Hepatic expression of detoxification enzymes is decreased in human obstructive cholestasis due to gallstone biliary obstructionSclerosing cholangitis in baboons (Papio spp) resembling primary sclerosing cholangitis of humans.Regulation of hepatic ABCC transporters by xenobiotics and in disease states.Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-sNuclear receptors CAR and PXR in the regulation of hepatic metabolism.Small-molecule modulators of PXR and CAR.Effects of human and porcine bile on the proteome of Helicobacter hepaticusOrganic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injuryNuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liverCoordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice.Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice.Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice.Sterolins ABCG5 and ABCG8: regulators of whole body dietary sterols.Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).The antiapoptotic role of pregnane X receptor in human colon cancer cells.Targeted drug delivery to treat pain and cerebral hypoxiaNuclear receptors as drug targets in cholestatic liver diseases.Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileo-cecal resection.Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampinActivation of Constitutive Androstane Receptor (CAR) in Mice Results in Maintained Biliary Excretion of Bile Acids Despite a Marked Decrease of Bile Acids in Liver
P2860
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P2860
CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
CAR and PXR agonists stimulate ...... elimination pathways in mice.
@en
CAR and PXR agonists stimulate ...... elimination pathways in mice.
@nl
type
label
CAR and PXR agonists stimulate ...... elimination pathways in mice.
@en
CAR and PXR agonists stimulate ...... elimination pathways in mice.
@nl
prefLabel
CAR and PXR agonists stimulate ...... elimination pathways in mice.
@en
CAR and PXR agonists stimulate ...... elimination pathways in mice.
@nl
P2093
P50
P356
P1433
P1476
CAR and PXR agonists stimulate ...... elimination pathways in mice.
@en
P2093
Cord Langner
Emina Halilbasic
Hanns-Ulrich Marschall
Helmut Denk
Martin Wagner
Michael Trauner
P304
P356
10.1002/HEP.20784
P407
P577
2005-08-01T00:00:00Z