Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation.
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Na⁺ transport in the normal and failing heart - remember the balanceThe role of late I Na in development of cardiac arrhythmiasRegulation of intracellular Na(+) in health and disease: pathophysiological mechanisms and implications for treatmentNew treatment options for late Na current, arrhythmias, and diastolic dysfunctionCalcium-regulated transcriptional pathways in the normal and pathologic heartLate Na(+) current and protracted electrical recovery are critical determinants of the aging myopathyRole of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death.Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivityProton-dependent inhibition of the cardiac sodium channel Nav1.5 by ranolazineVoltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.There goes the neighborhood: pathological alterations in T-tubule morphology and consequences for cardiomyocyte Ca2+ handling.Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium.Late sodium current contributes to diastolic cell Ca2+ accumulation in chronic heart failure.Emerging clinical role of ranolazine in the management of angina.New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes.Myocardial contraction-relaxation couplingRanolazine: a new approach to treating an old problem.Resveratrol attenuates the Na(+)-dependent intracellular Ca(2+) overload by inhibiting H(2)O(2)-induced increase in late sodium current in ventricular myocytesIntracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes.Ranolazine attenuates behavioral signs of neuropathic pain.Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure.Novel aspects of excitation-contraction coupling in heart failure.Regulation of ion gradients across myocardial ischemic border zones: a biophysical modelling analysis.Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatmentCalpain inhibition reduces amplitude and accelerates decay of the late sodium current in ventricular myocytes from dogs with chronic heart failureEffects of ranolazine on torsades de pointes tachycardias in a healthy isolated rabbit heart modelTargeting cardiomyocyte Ca2+ homeostasis in heart failure.Exacerbation of myocardial dysfunction and autonomic imbalance contributes to the estrogen-dependent chronic hypotensive effect of ethanol in female ratsEffect of late sodium current inhibition on MRI measured diastolic dysfunction in aortic stenosis: a pilot study.Effects of ranolazine on exercise capacity, right ventricular indices, and hemodynamic characteristics in pulmonary arterial hypertension: a pilot studyChanges in Intracellular Na+ following Enhancement of Late Na+ Current in Virtual Human Ventricular Myocytes.Effect of ranolazine on left ventricular dyssynchrony in patients with coronary artery disease.Mild metabolic acidosis impairs the β-adrenergic response in isolated human failing myocardium.Trimetazidine does not alter metabolic substrate oxidation in cardiac mitochondria of target patient population.Myocyte repolarization modulates myocardial function in aging dogsWenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial InfarctionRole of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease.Na+ transport in cardiac myocytes; Implications for excitation-contraction coupling.Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazineThe arrhythmogenic consequences of increasing late INa in the cardiomyocyte.
P2860
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P2860
Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Ranolazine improves diastolic ...... ntracellular ion accumulation.
@en
Ranolazine improves diastolic ...... ntracellular ion accumulation.
@nl
type
label
Ranolazine improves diastolic ...... ntracellular ion accumulation.
@en
Ranolazine improves diastolic ...... ntracellular ion accumulation.
@nl
prefLabel
Ranolazine improves diastolic ...... ntracellular ion accumulation.
@en
Ranolazine improves diastolic ...... ntracellular ion accumulation.
@nl
P2093
P1476
Ranolazine improves diastolic ...... ntracellular ion accumulation.
@en
P2093
Eva C L Rasenack
Friedrich A Schöndube
Gero Tenderich
Hanna Ruff
Lars S Maier
Luiz Belardinelli
Samuel Sossalla
Sarah L Weber
Stefan Wagner
Theodor Tirilomis
P356
10.1016/J.YJMCC.2008.03.006
P577
2008-03-14T00:00:00Z