A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites. - Wikidata - awgldk - TriplyDB

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites.

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites.

http://www.wikidata.org/entity/Q46633348

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Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles Replication of Structured DNA and its implication in epigenetic stability DNA polymerase θ (POLQ), double-strand break repair, and cancer DNA Polymerase θ: A Unique Multifunctional End-Joining Machine Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?Mechanism of suppression of chromosomal instability by DNA polymerase POLQ Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency Error-Prone Repair of DNA Double-Strand Breaks.Human DNA polymerase θ grasps the primer terminus to mediate DNA repair Having a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing.Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis A role for human homologous recombination factors in suppressing microhomology-mediated end joining G4-associated human diseases.Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining.Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs.Linking DNA polymerase theta structure and function in health and disease Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining Systematic discovery of complex insertions and deletions in human cancers.Construction of a large collection of small genome variations in French dairy and beef breeds using whole-genome sequences.Multiple mechanisms contribute to double-strand break repair at rereplication forks in Drosophila follicle cells.CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours Stop pulling my strings - what telomeres taught us about the DNA damage response.Making the bend: DNA tertiary structure and protein-DNA interactions.G-quadruplex interacting small molecules and drugs: from bench toward bedside.Duplex stem-loop-containing quadruplex motifs in the human genome: a combined genomic and structural study.Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli.Deciphering the Code of the Cancer Genome: Mechanisms of Chromosome Rearrangement.Co-inhibition of pol θ and HR genes efficiently synergize with cisplatin to suppress cisplatin-resistant lung cancer cells survival.Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells.Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans.Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms.Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers.T-DNA integration in plants results from polymerase-θ-mediated DNA repair.CRISPR/Cas9-Induced Double-Strand Break Repair in Arabidopsis Nonhomologous End-Joining Mutants.

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P2860

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites.

http://www.wikidata.org/entity/Q46633348

description

2014 nî lūn-bûn

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2014年の論文

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年學術文章

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2014年學術文章

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name

A Polymerase Theta-dependent r ...... ty at endogenous G4 DNA sites.

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A Polymerase Theta-dependent r ...... ty at endogenous G4 DNA sites.

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type

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A Polymerase Theta-dependent r ...... ty at endogenous G4 DNA sites.

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A Polymerase Theta-dependent r ...... ty at endogenous G4 DNA sites.

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A Polymerase Theta-dependent r ...... ty at endogenous G4 DNA sites.

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A Polymerase Theta-dependent r ...... ty at endogenous G4 DNA sites.

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Nature Communications

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A Polymerase Theta-dependent r ...... ty at endogenous G4 DNA sites.

@en

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Andrea E Karambelas

http://www.w3.org/2001/XMLSchema#string

Jane T van Heteren

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Kristy L Okihara

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Robin van Schendel

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Wouter Koole

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P2860

POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells

Promiscuous DNA synthesis by human DNA polymerase θ

Prevalence of quadruplexes in the human genome.

High-efficiency bypass of DNA damage by human DNA polymerase Q

A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis

RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity

The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm

Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads

Single-copy insertion of transgenes in Caenorhabditis elegans

Identification of genes expressed in the hermaphrodite germ line of C. elegans using SAGE.

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3216

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10.1038/NCOMMS4216

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5

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Marcel Tijsterman

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2014-01-01T00:00:00Z

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24496117

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