Docking and rolling, a model of how the mitotic motor Eg5 works.
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Kinesin-5: cross-bridging mechanism to targeted clinical therapyThe conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5Loop L5 acts as a conformational latch in the mitotic kinesin Eg5Analysis of the interaction of the Eg5 Loop5 with the nucleotide sitePathway of ATP hydrolysis by monomeric kinesin Eg5Force and premature binding of ADP can regulate the processivity of individual Eg5 dimersIndividual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitroStructure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configurationThe Structural Basis of Force Generation by the Mitotic Motor Kinesin-5"Snapshots"of Ispinesib-induced Conformational Changes in the Mitotic Kinesin Eg5Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family.Motile properties of the bi-directional kinesin-5 Cin8 are affected by phosphorylation in its motor domain.Kinesin-5 allosteric inhibitors uncouple the dynamics of nucleotide, microtubule, and neck-linker binding sites.FRET measurements of kinesin neck orientation reveal a structural basis for processivity and asymmetry.Kinesin-2 KIF3AB exhibits novel ATPase characteristicsKinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular MachinesModulation of the kinesin ATPase cycle by neck linker docking and microtubule binding.A seesaw model for intermolecular gating in the kinesin motor proteinInterhead tension determines processivity across diverse N-terminal kinesins.Eg5 steps it up!Processivity of the kinesin-2 KIF3A results from rear head gating and not front head gatingKinesin motor mechanics: binding, stepping, tracking, gating, and limping.Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysisThe loop 5 element structurally and kinetically coordinates dimers of the human kinesin-5, Eg5.The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5.Getting in sync with dimeric Eg5. Initiation and regulation of the processive run.To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5.Modular aspects of kinesin force generation machineryLoop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study.The ATPase cycle of the mitotic motor CENP-E.Kinesin spindle protein (KSP) inhibitors in combination with chemotherapeutic agents for cancer therapy.Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening.Microtubule C-Terminal Tails Can Change Characteristics of Motor Force Production.The Kinesin-5 Chemomechanical Cycle Is Dominated by a Two-heads-bound State.The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner.A pathway of structural changes produced by monastrol binding to Eg5.Kinesin family member 11 contributes to the progression and prognosis of human breast cancer.A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function.
P2860
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P2860
Docking and rolling, a model of how the mitotic motor Eg5 works.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Docking and rolling, a model of how the mitotic motor Eg5 works.
@en
Docking and rolling, a model of how the mitotic motor Eg5 works.
@nl
type
label
Docking and rolling, a model of how the mitotic motor Eg5 works.
@en
Docking and rolling, a model of how the mitotic motor Eg5 works.
@nl
prefLabel
Docking and rolling, a model of how the mitotic motor Eg5 works.
@en
Docking and rolling, a model of how the mitotic motor Eg5 works.
@nl
P2093
P2860
P356
P1476
Docking and rolling, a model of how the mitotic motor Eg5 works.
@en
P2093
Geraldine M Jefferson
Peter H King
Steven S Rosenfeld
P2860
P304
35684-35695
P356
10.1074/JBC.M506561200
P407
P577
2005-08-22T00:00:00Z