Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors.
about
Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effectsInsights into the PI3-K-PKB-mTOR signalling pathway from small molecules.Tinkering outside the kinase ATP box: allosteric (type IV) and bivalent (type V) inhibitors of protein kinases.A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.Selection of cyclic-peptide inhibitors targeting Aurora kinase A: problems and solutions.Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II.Pharmacophore modeling, virtual screening, and molecular docking studies for discovery of novel Akt2 inhibitors.
P2860
Q30499793-4057E401-8618-4CF6-BDD6-423EA1F9D75BQ33744734-2395B8B8-7D40-40BD-897C-620B2D57FBA3Q37537099-8D8789DF-D14F-4024-9D1C-441DF96CCDE3Q37856294-E03976DE-71EC-403A-BD90-319CBCDD517FQ37976467-AF462F31-85C4-4A8C-AA62-A1BA05BFD162Q38913428-DBEEFE26-CAF7-42A9-A50D-33767B98B4D4Q39728922-87540821-67C3-435B-A482-0F67FD45F3ADQ41830699-6F4BD99A-E7D3-4187-9E9F-4241D576264D
P2860
Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Optimization of 2,3,5-trisubst ...... eric Akt1 and Akt2 inhibitors.
@en
Optimization of 2,3,5-trisubst ...... eric Akt1 and Akt2 inhibitors.
@nl
type
label
Optimization of 2,3,5-trisubst ...... eric Akt1 and Akt2 inhibitors.
@en
Optimization of 2,3,5-trisubst ...... eric Akt1 and Akt2 inhibitors.
@nl
prefLabel
Optimization of 2,3,5-trisubst ...... eric Akt1 and Akt2 inhibitors.
@en
Optimization of 2,3,5-trisubst ...... eric Akt1 and Akt2 inhibitors.
@nl
P2093
P1476
Optimization of 2,3,5-trisubst ...... eric Akt1 and Akt2 inhibitors.
@en
P2093
Astrid M Kral
Deborah Defeo-Jones
George D Hartman
Hans E Huber
John C Hartnett
Mark T Bilodeau
Raymond E Jones
Ronald G Robinson
Stanley F Barnett
P304
P356
10.1016/J.BMCL.2007.12.040
P407
P577
2007-12-23T00:00:00Z