Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. - Wikidata - awgldk - TriplyDB

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.

http://www.wikidata.org/entity/Q46738145

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The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein Impact of apolipoprotein E on Alzheimer's disease Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease ApoE promotes the proteolytic degradation of Abeta Vasculoprotection as a Convergent, Multi-Targeted Mechanism of Anti-AD Therapeutics and Interventions Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance Role of Abca7 in mouse behaviours relevant to neurodegenerative diseases.ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice.Effect of apolipoprotein E genotype and diet on apolipoprotein E lipidation and amyloid peptides: randomized clinical trial Opposing effects of Apoe/Apoa1 double deletion on amyloid-β pathology and cognitive performance in APP mice.Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway.Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus.Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice.LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model.Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.Apolipoprotein E: from lipid transport to neurobiology More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury The role of apolipoprotein E in Alzheimer's disease.MicroRNAs: a connection between cholesterol metabolism and neurodegeneration.HDL and cognition in neurodegenerative disorders.Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.LDL receptor knock-out mice show impaired spatial cognition with hippocampal vulnerability to apoptosis and deficits in synapses.Function and comorbidities of apolipoprotein e in Alzheimer's disease.Domains of apoE4 required for the biogenesis of apoE-containing HDL.Improvement of memory deficits and amyloid-β clearance in aged APP23 mice treated with a combination of anti-amyloid-β antibody and LXR agonist An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia.Nuclear receptors as therapeutic targets for Alzheimer's disease APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice.A-Subclass ATP-Binding Cassette Proteins in Brain Lipid Homeostasis and Neurodegeneration.MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1.Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors.

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P2860

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.

http://www.wikidata.org/entity/Q46738145

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Deletion of Abca1 increases Ab ...... se model of Alzheimer disease.

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Deletion of Abca1 increases Ab ...... se model of Alzheimer disease.

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type

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Deletion of Abca1 increases Ab ...... se model of Alzheimer disease.

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Deletion of Abca1 increases Ab ...... se model of Alzheimer disease.

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prefLabel

Deletion of Abca1 increases Ab ...... se model of Alzheimer disease.

@en

Deletion of Abca1 increases Ab ...... se model of Alzheimer disease.

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Journal of Biological Chemistry

P1476

Deletion of Abca1 increases Ab ...... se model of Alzheimer disease.

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P2093

Hong Jiang

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Kelly R Bales

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Maia Parsadanian

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Richard E Hartman

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Steven M Paul

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Suzanne E Wahrle

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P2860

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

Structure, function and regulation of the ABC1 gene product

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

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280

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16207708

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Alzheimer's disease