Glucose up-regulates HIF-1 alpha expression in primary cortical neurons in response to hypoxia through maintaining cellular redox status.
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The possible mechanisms underlying the impairment of HIF-1α pathway signaling in hyperglycemia and the beneficial effects of certain therapiesIschemia induces different levels of hypoxia inducible factor-1α protein expression in interneurons and pyramidal neurons.Relative Contribution of Prolyl Hydroxylase-Dependent and -Independent Degradation of HIF-1alpha by Proteasomal Pathways in Cerebral Ischemia.Induction of the vascular endothelial growth factor pathway in the brain of adults with fatal falciparum malaria is a non-specific response to severe disease.Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner.Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in ratsHypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity.Metabolism Regulates Cellular Functions of Bone Marrow-Derived Cells used for Cardiac Therapy.Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine.Gene regulatory control in the sea urchin aboral ectoderm: spatial initiation, signaling inputs, and cell fate lockdown.High glucose enhances HIV entry into T cells through upregulation of CXCR4.Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass.Hypoxia-inducible factor 1 contributes to N-acetylcysteine's protection in stroke.Hypoxia inducible factor 1 as a therapeutic target in ischemic stroke.Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes.Hypoxia inducible factor-1: its potential role in cerebral ischemia.Metabolic regulation of mesenchymal stem cell in expansion and therapeutic application.Asymmetric distribution of hypoxia-inducible factor α regulates dorsoventral axis establishment in the early sea urchin embryo.mtDNA as a Mediator for Expression of Hypoxia-Inducible Factor 1α and ROS in Hypoxic Neuroblastoma Cells.Hypoxic Adaptation in the Nervous System: Promise for Novel Therapeutics for Acute and Chronic Neurodegeneration.Excess glucose induces hypoxia-inducible factor-1α in pancreatic cancer cells and stimulates glucose metabolism and cell migrationDifferential changes of glutathione levels in astrocytes and neurons in ischemic brains by two-photon imaging.Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environmentA reducing environment stabilizes HIF-2alpha in SH-SY5Y cells under hypoxic conditions.Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer.The early activation of PI3K strongly enhances the resistance of cortical neurons to hypoxic injury via the activation of downstream targets of the PI3K pathway and the normalization of the levels of PARP activity, ATP, and NAD⁺.Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons.Changes in HIF-1α, VEGF, NGF and BDNF levels in cerebrospinal fluid and their relationship with cognitive impairment in patients with cerebral infarction.Energy restriction as an antitumor target.Brain Energy and Oxygen Metabolism: Emerging Role in Normal Function and Disease.Hypoxia-Inducible Factor: Pattern of the Effects and Their Dualism
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P2860
Glucose up-regulates HIF-1 alpha expression in primary cortical neurons in response to hypoxia through maintaining cellular redox status.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Glucose up-regulates HIF-1 alp ...... taining cellular redox status.
@en
Glucose up-regulates HIF-1 alp ...... taining cellular redox status.
@nl
type
label
Glucose up-regulates HIF-1 alp ...... taining cellular redox status.
@en
Glucose up-regulates HIF-1 alp ...... taining cellular redox status.
@nl
prefLabel
Glucose up-regulates HIF-1 alp ...... taining cellular redox status.
@en
Glucose up-regulates HIF-1 alp ...... taining cellular redox status.
@nl
P2093
P2860
P1476
Glucose up-regulates HIF-1 alp ...... taining cellular redox status.
@en
P2093
Honglian Shi
Ke Jian Liu
Marilee Morgan
Shuhong Guo
Yuexian Xu
Zongxian Cao
P2860
P304
P356
10.1111/J.1471-4159.2008.05287.X
P407
P577
2008-02-07T00:00:00Z