KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group.
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Molecular diagnosis of mast cell disorders: a paper from the 2005 William Beaumont Hospital Symposium on Molecular PathologyPrognostic Significance of KIT Mutations in Core-Binding Factor Acute Myeloid Leukemia: A Systematic Review and Meta-AnalysisHigh level of miR-196b at newly diagnosed pediatric acute myeloid leukemia predicts a poor outcomePrevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML.Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations.Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias.Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemiaArray-based genomic resequencing of human leukemia.Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome.High expression of c-kit mRNA predicts unfavorable outcome in adult patients with t(8;21) acute myeloid leukemia.Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia.High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy.Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.Pediatric developmental therapies: interesting new drugs now in early-stage clinical trials.Rapid detection of KIT mutations in core-binding factor acute myeloid leukemia using high-resolution melting analysisClinical management of primary non-acute promyelocytic leukemia acute myeloid leukemia: Practice Guidelines by the Italian Society of Hematology, the Italian Society of Experimental Hematology, and the Italian Group for Bone Marrow Transplantation.The novel HSP90 inhibitor STA-9090 exhibits activity against Kit-dependent and -independent malignant mast cell tumorsRUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia.TrkC promotes survival and growth of leukemia cells through Akt-mTOR-dependent up-regulation of PLK-1 and Twist-1.Clinical Impact of Additional Cytogenetic Aberrations, cKIT and RAS Mutations, and Treatment Elements in Pediatric t(8;21)-AML: Results From an International Retrospective Study by the International Berlin-Frankfurt-Münster Study Group.Molecular-based classification of acute myeloid leukemia and its role in directing rational therapy: personalized medicine for profoundly promiscuous proliferations.How I treat paediatric relapsed acute myeloid leukaemia.Prognosis and monitoring of core-binding factor acute myeloid leukemia: current and emerging factors.Microarray profiling and co-expression network analysis of the lncRNAs and mRNAs associated with acute leukemia in adults.KIT D816 mutation associates with adverse outcomes in core binding factor acute myeloid leukemia, especially in the subgroup with RUNX1/RUNX1T1 rearrangement.A genome-wide single-nucleotide polymorphism-array can improve the prognostic stratification of the core binding factor acute myeloid leukemia.Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling, Fatty Acid Synthesis and Cellular Iron Uptake.Celastrol Induces Cell Apoptosis and Inhibits the Expression of the AML1-ETO/C-KIT Oncoprotein in t(8;21) Leukemia.KIT mutations correlate with adverse survival in children with core-binding factor acute myeloid leukemia.Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.The quality of molecular response to chemotherapy is predictive for the outcome of AML1-ETO-positive AML and is independent of pretreatment risk factors.Molecular profiling reveals myeloid leukemia cell lines to be faithful model systems characterized by distinct genomic aberrations.Prognostic impact of specific molecular profiles in pediatric acute megakaryoblastic leukemia in non-Down syndrome.Whole-exome sequencing reveals the spectrum of gene mutations and the clonal evolution patterns in paediatric acute myeloid leukaemia.High frequency of concomitant mastocytosis in patients with acute myeloid leukemia exhibiting the transforming KIT mutation D816V.Update on optimal management of acute myeloid leukemiaAcute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications.Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis.WT1 mutation in pediatric patients with acute myeloid leukemia: a report from the Japanese Childhood AML Cooperative Study Group.
P2860
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P2860
KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
KIT mutations, and not FLT3 in ...... d AML Cooperative Study Group.
@en
KIT mutations, and not FLT3 in ...... d AML Cooperative Study Group.
@nl
type
label
KIT mutations, and not FLT3 in ...... d AML Cooperative Study Group.
@en
KIT mutations, and not FLT3 in ...... d AML Cooperative Study Group.
@nl
prefLabel
KIT mutations, and not FLT3 in ...... d AML Cooperative Study Group.
@en
KIT mutations, and not FLT3 in ...... d AML Cooperative Study Group.
@nl
P2093
P1433
P1476
KIT mutations, and not FLT3 in ...... d AML Cooperative Study Group.
@en
P2093
Akira Shimada
Ichiro Tsukimoto
Keizo Horibe
Ken Tabuchi
Masahiro Tsuchida
Ryoji Hanada
Tomohiko Taki
Yasuhide Hayashi
P304
P356
10.1182/BLOOD-2005-08-3408
P407
P577
2005-11-15T00:00:00Z