Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.
about
Targeting xenobiotic receptors PXR and CAR for metabolic diseasesMaternal nutrition induces pervasive gene expression changes but no detectable DNA methylation differences in the liver of adult offspringPregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator InteractionsInsights into CYP2B6-mediated drug-drug interactionsNon-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 miceEvaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver diseasePrenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthoodLiver transcriptome analysis of Atlantic cod (Gadus morhua) exposed to PCB 153 indicates effects on cell cycle regulation and lipid metabolismNovel functions of PXR in cardiometabolic disease.Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers.Intestinal microbiota regulate xenobiotic metabolism in the liver.Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.A functional cross-talk between liver X receptor-α and constitutive androstane receptor links lipogenesis and xenobiotic responses.Activation of pregnane X receptor by pregnenolone 16 α-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice.Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism.Deficiency of PXR decreases atherosclerosis in apoE-deficient mice.Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.Nuclear receptors in nonalcoholic Fatty liver diseaseSmall-molecule modulators of the constitutive androstane receptor.Small-molecule modulators of PXR and CAR.Deciphering the roles of the constitutive androstane receptor in energy metabolism.Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized miceDrug metabolism alterations in nonalcoholic fatty liver diseaseActivation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice.The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity.The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity.Pathogenesis of alcoholic liver disease: the role of nuclear receptors.Role of pregnane X receptor in obesity and glucose homeostasis in male mice.Sterol regulation of metabolism, homeostasis, and development.Signaling control of the constitutive androstane receptor (CAR)PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands.The effects of cytochrome P450 induction by xenobiotics on endobiotic metabolism in pre-clinical safety studies.Orphan nuclear receptors as targets for drug development.Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids.Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond.Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor.Minireview: endoplasmic reticulum stress: control in protein, lipid, and signal homeostasis.
P2860
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P2860
Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Regulatory cross-talk between ...... r increase Insig-1 expression.
@en
Regulatory cross-talk between ...... r increase Insig-1 expression.
@nl
type
label
Regulatory cross-talk between ...... r increase Insig-1 expression.
@en
Regulatory cross-talk between ...... r increase Insig-1 expression.
@nl
prefLabel
Regulatory cross-talk between ...... r increase Insig-1 expression.
@en
Regulatory cross-talk between ...... r increase Insig-1 expression.
@nl
P2093
P356
P1476
Regulatory cross-talk between ...... r increase Insig-1 expression.
@en
P2093
Adrian Roth
David D Moore
Franck Rencurel
Michel Kaufmann
Renate Looser
Sharon M Blättler
Urs A Meyer
Wendong Huang
P304
P356
10.1124/MOL.107.041012
P577
2008-01-10T00:00:00Z