Innovative native MS methodologies for antibody drug conjugate characterization: High resolution native MS and IM-MS for average DAR and DAR distribution assessment.
about
Controlled levels of protein modification through a chromatography-mediated bioconjugation.Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate.A rapid on-line method for mass spectrometric confirmation of a cysteine-conjugated antibody-drug-conjugate structure using multidimensional chromatography.A sensitive multidimensional method for the detection, characterization, and quantification of trace free drug species in antibody-drug conjugate samples using mass spectral detectionBioanalytical approaches for characterizing catabolism of antibody-drug conjugates.Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates.Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS.Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates.Strategies and challenges for the next generation of antibody-drug conjugates.Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality ControlPrecise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometry.Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates.Analysis of Proteins, Protein Complexes, and Organellar Proteomes Using Sheathless Capillary Zone Electrophoresis - Native Mass Spectrometry.Advances in native high-performance liquid chromatography and intact mass spectrometry for the characterization of biopharmaceutical products.Adding a new separation dimension to MS and LC-MS: What is the utility of ion mobility spectrometry?Analytical techniques for the characterization of Antibody Drug Conjugates: Challenges and prospects.Immunoprecipitation middle-up LC-MS for in vivo drug-to-antibody ratio determination for antibody-drug conjugates.Localized conformational interrogation of antibody and antibody-drug conjugates by site-specific carboxyl group footprinting.Unconjugated payload quantification and DAR characterization of antibody-drug conjugates using high-resolution MS.Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry.Native mass spectrometry combined with enzymatic dissection unravels glycoform heterogeneity of biopharmaceuticals.Use of a charge reducing agent to enable intact mass analysis of cysteine-linked antibody-drug-conjugates by native mass spectrometry.
P2860
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P2860
Innovative native MS methodologies for antibody drug conjugate characterization: High resolution native MS and IM-MS for average DAR and DAR distribution assessment.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh-hant
name
Innovative native MS methodolo ...... d DAR distribution assessment.
@en
Innovative native MS methodolo ...... d DAR distribution assessment.
@nl
type
label
Innovative native MS methodolo ...... d DAR distribution assessment.
@en
Innovative native MS methodolo ...... d DAR distribution assessment.
@nl
prefLabel
Innovative native MS methodolo ...... d DAR distribution assessment.
@en
Innovative native MS methodolo ...... d DAR distribution assessment.
@nl
P2093
P356
P1433
P1476
Innovative native MS methodolo ...... nd DAR distribution assessment
@en
P2093
Alain Beck
Alain Van Dorsselaer
Amandine Boeuf
Elsa Wagner-Rousset
François Debaene
Nathalie Corvaïa
Olivier Colas
P304
10674-10683
P356
10.1021/AC502593N
P407
P577
2014-10-21T00:00:00Z