Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations.
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(19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP HydrolysisOverview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras.Ras and GTPase-activating protein (GAP) drive GTP into a precatalytic state as revealed by combining FTIR and biomolecular simulations.The GAP arginine finger movement into the catalytic site of Ras increases the activation entropyMechanism of the chemical step for the guanosine triphosphate (GTP) hydrolysis catalyzed by elongation factor TuLessons from computer simulations of Ras proteins in solution and in membraneThe hydrolysis activity of adenosine triphosphate in myosin: a theoretical analysis of anomeric effects and the nature of the transition stateWhy nature really chose phosphate.Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, 19 F NMR, and DFT Approaches.Metal Fluorides: Tools for Structural and Computational Analysis of Phosphoryl Transfer Enzymes.The role of magnesium for geometry and charge in GTP hydrolysis, revealed by quantum mechanics/molecular mechanics simulations.N-Ras forms dimers at POPC membranes.Free energy simulations of a GTPase: GTP and GDP binding to archaeal initiation factor 2.Label-free screening of drug-protein interactions by time-resolved Fourier transform infrared spectroscopic assays exemplified by Ras interactions.Probing the wild-type HRas activation mechanism using steered molecular dynamics, understanding the energy barrier and role of water in the activation.Substrate recognition by norovirus polymerase: microsecond molecular dynamics study.Importance of an Orchestrate Participation of Each Individual Residue Present at a Catalytic Site.QM/MM-Methoden für biomolekulare Systeme
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P2860
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations.
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2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年學術文章
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name
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations.
@en
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations.
@nl
type
label
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations.
@en
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations.
@nl
prefLabel
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations.
@en
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations.
@nl
P2860
P1433
P1476
Role of the arginine finger in Ras.RasGAP revealed by QM/MM calculations.
@en
P2093
Henrik te Heesen
Jürgen Schlitter
P2860
P304
P356
10.1016/J.FEBSLET.2007.11.026
P407
P577
2007-11-20T00:00:00Z