A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
about
Expanding Spectrum of Sodium Potassium Chloride Co-transporters in the Pathophysiology of DiseasesAlterations in sociability and functional brain connectivity caused by early-life seizures are prevented by bumetanide.NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives.Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizuresCation-chloride cotransporters in neuronal development, plasticity and diseaseAcute and chronic efficacy of bumetanide in an in vitro model of posttraumatic epileptogenesis.Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporterThe WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.Depolarizing GABA and developmental epilepsies.GABAergic Synchronization in Epilepsy.Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives.Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).Chloride co-transporters as possible therapeutic targets for stroke.The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice.Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus.Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain.The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat.Neonatal inhibition of Na+-K+-2Cl--cotransporter prevents ketamine induced spatial learning and memory impairments.Bumetanide blocks the acquisition of conditioned fear in adult rats.Depolarizing γ-aminobutyric acid contributes to glutamatergic network rewiring in epilepsy.The Search for New Screening Models of Pharmacoresistant Epilepsy: Is Induction of Acute Seizures in Epileptic Rodents a Suitable Approach?Antisecretory Factor-mediated Inhibition of Cell Volume Dynamics Produces Anti-tumor Activity in Glioblastoma.Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B.
P2860
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P2860
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
@zh-my
2014年学术文章
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2014年學術文章
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2014年學術文章
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name
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
@en
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
@nl
type
label
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
@en
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
@nl
prefLabel
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
@en
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
@nl
P2093
P2860
P356
P1433
P1476
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
@en
P2093
Claudia Brandt
Gerda Brunhofer
Jenna Lindfors
Kathrin Töllner
Manuel Töpfer
Mario Gabriel
Peter W Feit
Thomas Erker
Wolfgang Löscher
P2860
P304
P356
10.1002/ANA.24124
P50
P577
2014-04-02T00:00:00Z