A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. - Wikidata - awgldk - TriplyDB

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.

http://www.wikidata.org/entity/Q46921173

about

Expanding Spectrum of Sodium Potassium Chloride Co-transporters in the Pathophysiology of Diseases Alterations in sociability and functional brain connectivity caused by early-life seizures are prevented by bumetanide.NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives.Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures Cation-chloride cotransporters in neuronal development, plasticity and disease Acute and chronic efficacy of bumetanide in an in vitro model of posttraumatic epileptogenesis.Structure-activity relationships of bumetanide derivatives: correlation between diuretic activity in dogs and inhibition of the human NKCC2A transporter The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.Depolarizing GABA and developmental epilepsies.GABAergic Synchronization in Epilepsy.Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives.Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII).Chloride co-transporters as possible therapeutic targets for stroke.The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice.Bumetanide reduces seizure progression and the development of pharmacoresistant status epilepticus.Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain.The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat.Neonatal inhibition of Na+-K+-2Cl--cotransporter prevents ketamine induced spatial learning and memory impairments.Bumetanide blocks the acquisition of conditioned fear in adult rats.Depolarizing γ-aminobutyric acid contributes to glutamatergic network rewiring in epilepsy.The Search for New Screening Models of Pharmacoresistant Epilepsy: Is Induction of Acute Seizures in Epileptic Rodents a Suitable Approach?Antisecretory Factor-mediated Inhibition of Cell Volume Dynamics Produces Anti-tumor Activity in Glioblastoma.Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B.

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P2860

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.

http://www.wikidata.org/entity/Q46921173

description

2014 nî lūn-bûn

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2014年の論文

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

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2014年学术文章

@zh-my

2014年学术文章

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2014年學術文章

@yue

2014年學術文章

@zh-hant

name

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.

@en

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.

@nl

type

label

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.

@en

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.

@nl

prefLabel

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.

@en

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.

@nl

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P1433

Annals of Neurology

P1476

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.

@en

P2093

Claudia Brandt

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Gerda Brunhofer

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Jenna Lindfors

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Kathrin Töllner

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Manuel Töpfer

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Mario Gabriel

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Peter W Feit

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Thomas Erker

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Wolfgang Löscher

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P2860

The neurobiology of antiepileptic drugs

NKCC1 transporter facilitates seizures in the developing brain

A randomised controlled trial of bumetanide in the treatment of autism in children

Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital.

On the origin of interictal activity in human temporal lobe epilepsy in vitro.

Aminobenzoic acid diuretics. 2. 4-Substituted-3-amino-5-sulfamylbenzoic acid derivatives.

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments.

Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures.

Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory.

Cation-chloride co-transporters in neuronal communication, development and trauma.

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550-562

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10.1002/ANA.24124

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4

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75

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24615913

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