CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.
about
Drosophila as a genetic and cellular model for studies on axonal growthCRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formationHem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxisStructure and control of the actin regulatory WAVE complexNYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neuronsEvolutionarily conserved human targets of adenosine to inosine RNA editingThe comorbidity of autism with the genomic disorders of chromosome 15q11.2-q13Fragile X syndrome: loss of local mRNA regulation alters synaptic development and functionWhat can we learn about autism from studying fragile X syndrome?Advances in the treatment of fragile X syndromeFragile x syndromeInhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.Dysregulation and restoration of translational homeostasis in fragile X syndromeLearning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us.The FMRP regulon: from targets to disease convergenceFragile X-like behaviors and abnormal cortical dendritic spines in cytoplasmic FMR1-interacting protein 2-mutant mice.Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in miceThe neurobiology of the Prader-Willi phenotype of fragile X syndromeSubcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolinIn vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation proteinFrom mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndromeCyfip1 Regulates Presynaptic Activity during DevelopmentThe autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spinesUp-regulated cytoplasmic FMRP-interacting protein 1 in intractable temporal lobe epilepsy patients and a rat modelSra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation.ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memoryRescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formationSystematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts.Transcript diversification in the nervous system: a to I RNA editing in CNS function and disease developmentAsymmetric Mbc, active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in DrosophilaTesting candidate genes for attention-deficit/hyperactivity disorder in fruit flies using a high throughput assay for complex behaviorA transgenic mouse model of metastatic carcinoma involving transdifferentiation of a gastric epithelial lineage progenitor to a neuroendocrine phenotypeGenomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint regionGenetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks.The genetic control of neocortex volume and covariation with neocortical gene expression in mice.Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis.New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes.FMR1 premutation with Prader-Willi phenotype and fragile X-associated tremor/ataxia syndrome.dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster.
P2860
06d013b9dc699a337a5901d96ef3c9b8e088aacb131b9d5f4fb0906d89c79a47eb876a2c924fe4132056e3b2bcca08f28904917b52ce54f9eaf2d6706a60e9a0442c7a72461223638411e48712f1fac56df1ae5bb6756fc9094dc8df1aee1feca3ab00b57358657a96956e18ac5bbfe2b890f19ba14f7ddd976b1b5d3206a2585561213cd9e41f88af586b12be0be5cbd68d73e66cde698dac7c81689886a6c6e93d0e1c8a91f8b5fa052d3906d1c743453cd520
P248
Q21203077-EBEE9D11-E04D-4C72-80DF-83A1CBEB4AEFQ24293195-97354221-7B26-40F2-8983-0A32ED9CD78EQ24301351-25728EE4-4271-49C8-AB40-415DDC2ABF08Q24308919-A904A62D-AB08-490C-8AF2-40D7FA50956DQ24338593-B0EB0025-663B-4009-970E-DF29DE2CC738Q24556614-DABDD732-09AF-48C0-BE54-9BF5E3BF943FQ24594577-A44B2BE6-5825-4C7E-A4AF-396E5715ACD8Q24608468-38EE680D-3B4C-41A5-94AA-44BC931C9860Q24613049-05123813-7CA1-4BCA-9B57-4D8E88E9947BQ24632814-D539E1C8-4297-4488-9020-DCE9ED53F7E1Q24633000-45CFC27D-48C3-4DA0-90C7-9D865535C344Q24684102-3ABB9EC3-C5D2-410A-AE57-E51429991BE9Q26782616-6C8CAB68-7512-480D-B75B-CA6290CBABBCQ26866506-F419AA10-F94D-44B6-BF83-17BE0B7387D4Q27014002-39C07D0A-BB34-42E6-B0E2-A64383D526E7Q27301086-21B5C47D-C0B0-477E-A454-74583611CDAAQ27325468-CE8CD128-AB27-432C-9FBB-E3453B7F38AFQ28078294-E1A6B251-416D-4C8C-86E5-799875DAF150Q28114773-57FF64E1-9035-4A0F-B663-AEBB61BA1EC8Q28116617-95B232D7-E330-4990-BCA2-888D153D6D33Q28247567-88CCA496-FCFB-4359-A95F-5FB6F7BF9657Q28566588-B5D468FE-4E06-4151-9CFA-E0B28E606DADQ28572147-00FCF657-CC88-4C00-98F6-6D4B6293921FQ28572188-C8712F45-EFE8-41A0-BAE4-99C0545114E2Q28588154-899F3A52-C24C-4BC4-B692-C9C7F759B3E0Q28588962-7D43F135-BFA4-477E-9441-79ED80F49550Q28593254-4B3FEF3F-5308-4EC9-AF5B-2BD6F7C8A333Q28910185-EE16995A-B917-4550-BFE2-0418BD5E2720Q30394234-D92A34C4-199A-4029-96FA-BF919F5C5057Q30465782-94290F3B-3891-4436-A595-2537A72A3B6FQ30498965-47F2C918-95DC-4EE1-9E1E-951119C96811Q30781330-6D7A63C5-C1EE-4A9A-A28B-7D2742EDD443Q33201186-778E1731-6587-4B64-A64E-83B89D32555AQ33316874-BB220108-4F5A-463B-8BFF-664C6F9AF13EQ33387068-6065C2FC-F83D-49F9-BEC1-7317789CE992Q33441983-3288CBCA-FC73-457F-8C1F-CAAB6A071654Q33546654-8CAEACA5-304E-43E3-909A-4EB2C4B5C448Q33588069-F8E89EF9-FFB0-4384-8B78-0C9DC3DA99F5Q33625894-F3FD2D2C-EC50-422E-97DD-29352E0FC7D8Q33755357-DF5B3927-1B9F-4EAE-AD61-0CCD0FE8B8F1
P2860
CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
CYFIP/Sra-1 controls neuronal ...... hway to the fragile X protein.
@en
CYFIP/Sra-1 controls neuronal ...... hway to the fragile X protein.
@nl
type
label
CYFIP/Sra-1 controls neuronal ...... hway to the fragile X protein.
@en
CYFIP/Sra-1 controls neuronal ...... hway to the fragile X protein.
@nl
prefLabel
CYFIP/Sra-1 controls neuronal ...... hway to the fragile X protein.
@en
CYFIP/Sra-1 controls neuronal ...... hway to the fragile X protein.
@nl
P2093
P50
P1433
P1476
CYFIP/Sra-1 controls neuronal ...... thway to the fragile X protein
@en
P2093
Angela Giangrande
Caillin Langmann
Nicholas Harden
P304
P356
10.1016/S0896-6273(03)00354-4
P407
P577
2003-06-01T00:00:00Z