Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
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The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and exportGenome instability and transcription elongation impairment in human cells depleted of THO/TREXATP is required for interactions between UAP56 and two conserved mRNA export proteins, Aly and CIP29, to assemble the TREX complexHuman hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNARecruitment of the human TREX complex to mRNA during splicingChtop is a component of the dynamic TREX mRNA export complexRecruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replicationAdaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNANuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP)mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3Intellectual disability associated with a homozygous missense mutation in THOC6mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesCancer cells and normal cells differ in their requirements for Thoc1Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutantsAn hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination.Functional specificity of shuttling hnRNPs revealed by genome-wide analysis of their RNA binding profiles.The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.The role of TREX in gene expression and diseaseTHOC2 Mutations Implicate mRNA-Export Pathway in X-Linked Intellectual DisabilityAn ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivoThe THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogrammingPutative Arabidopsis THO/TREX mRNA export complex is involved in transgene and endogenous siRNA biosynthesisTHOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplexConservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexesXenopus meiotic microtubule-associated interactome.An allelic series for studying the mouse Thoc1 geneThe Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouseMOS11: a new component in the mRNA export pathwayA Sub-Element in PRE enhances nuclear export of intronless mRNAs by recruiting the TREX complex via ZC3H18Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers.An interaction between KSHV ORF57 and UIF provides mRNA-adaptor redundancy in herpesvirus intronless mRNA export.Characterization of EMU, the Arabidopsis homolog of the yeast THO complex member HPR1.Genome-wide analysis of mRNA decay patterns during early Drosophila development.Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets.Transcriptional regulation of hTREX84 in human cancer cells.The Drosophila P68 RNA helicase regulates transcriptional deactivation by promoting RNA release from chromatinThoc1/Hpr1/p84 is essential for early embryonic development in the mouse.
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P2860
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-hans
2004年学术文章
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name
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
@en
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
@nl
type
label
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
@en
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
@nl
prefLabel
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
@en
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
@nl
P2093
P2860
P50
P356
P1476
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.
@en
P2093
Andrea Herold
Michaela Rode
Thomas Köcher
P2860
P2888
P304
P356
10.1038/NSMB759
P577
2004-05-09T00:00:00Z
P6179
1049780708