Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256.
about
Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies.Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia.Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core.Positive allosteric modulation of M1 and M4 muscarinic receptors as potential therapeutic treatments for schizophrenia.A novel M1 PAM VU0486846 exerts efficacy in cognition models without displaying agonist activity or cholinergic toxicity.PF-06827443 Displays Robust Allosteric Agonist and Positive Allosteric Modulator Activity in High Receptor Reserve and Native Systems.
P2860
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P2860
Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh-hant
name
Prefrontal Cortex-Mediated Imp ...... by the Novel M1 PAM VU6004256.
@en
Prefrontal Cortex-Mediated Imp ...... by the Novel M1 PAM VU6004256.
@nl
type
label
Prefrontal Cortex-Mediated Imp ...... by the Novel M1 PAM VU6004256.
@en
Prefrontal Cortex-Mediated Imp ...... by the Novel M1 PAM VU6004256.
@nl
prefLabel
Prefrontal Cortex-Mediated Imp ...... by the Novel M1 PAM VU6004256.
@en
Prefrontal Cortex-Mediated Imp ...... by the Novel M1 PAM VU6004256.
@nl
P2093
P2860
P50
P1476
Prefrontal Cortex-Mediated Imp ...... by the Novel M1 PAM VU6004256.
@en
P2093
Amy J Ramsey
Anna L Blobaum
Carrie K Jones
Catharine A Mielnik
Hyekyung P Cho
Jacob Ball
Kellie D Nance
Masahito Abe
Michael Bubser
Michael D Grannan
P2860
P304
P356
10.1021/ACSCHEMNEURO.6B00230
P577
2016-09-12T00:00:00Z