Optimization of a higher throughput microsomal stability screening assay for profiling drug discovery candidates.
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17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine OrthologPredicting Mouse Liver Microsomal Stability with "Pruned" Machine Learning Models and Public Data.Recent advances in pharmacokinetic extrapolation from preclinical data to humans.An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis SoftwareThe conduct of drug metabolism studies considered good practice (II): in vitro experimentsSigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin.Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle.Recent development in high-throughput bioanalytical support for in vitro ADMET profiling.Application of a rapid and integrated analysis system (RIAS) as a high-throughput processing tool for in vitro ADME samples by liquid chromatography/tandem mass spectrometry.In vitro mutagenic, antimutagenic, and antioxidant activities evaluation and biotransformation of some bioactive 4-substituted 1-(2-methoxyphenyl)piperazine derivatives.Lipid-based oral delivery systems for skin deposition of a potential chemopreventive DIM derivative: characterization and evaluation.Determination of drug-like properties of a novel antileishmanial compound: In vitro absorption, distribution, metabolism, and excretion studies.Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection.Development and application of an automated solution stability assay for drug discovery.vNN Web Server for ADMET Predictions.Synthesis and biological evaluation of 2-fluoro and 3-trifluoromethyl-phenyl-piperazinylalkyl derivatives of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione as potential antidepressant agents.New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors.In Vitro Biotransformation, Safety, and Chemopreventive Action of Novel 8-Methoxy-Purine-2,6-Dione Derivatives.In Vitro Drug Metabolism Using Liver Microsomes.
P2860
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P2860
Optimization of a higher throughput microsomal stability screening assay for profiling drug discovery candidates.
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2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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name
Optimization of a higher throu ...... ing drug discovery candidates.
@en
Optimization of a higher throu ...... ing drug discovery candidates.
@nl
type
label
Optimization of a higher throu ...... ing drug discovery candidates.
@en
Optimization of a higher throu ...... ing drug discovery candidates.
@nl
prefLabel
Optimization of a higher throu ...... ing drug discovery candidates.
@en
Optimization of a higher throu ...... ing drug discovery candidates.
@nl
P2093
P2860
P356
P1476
Optimization of a higher throu ...... ing drug discovery candidates.
@en
P2093
Edward H Kerns
Oliver J McConnell
Teresa A Kleintop
P2860
P304
P356
10.1177/1087057103255988
P50
P577
2003-08-01T00:00:00Z